Crk anticorps

N° du produit ABIN969062

Détail du produit anti-Crk anticorps

Antigène: Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Crk est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Fonction: CRK Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human CRK expressed in E. Coli.

Clone: 3G11C1

Isotype: IgG2b

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Crk (ABIN969062)

Watanabe, Tsuda, Tanaka, Ohba, Kawaguchi, Majima, Sawa, Minami: "Adaptor protein Crk induces Src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation." dans: Molecular cancer research : MCR, Vol. 7, Issue 9, pp. 1582-92, (2009) (PubMed).

Tanaka: "[Biological roles of signaling adaptor protein CRK]." dans: Seikagaku. The Journal of Japanese Biochemical Society, Vol. 81, Issue 5, pp. 361-76, (2009) (PubMed).

Détails sur Crk

Antigène: Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Autre désignation: CRK (CRK Produits)

Synonymes: anticorps CG1587, anticorps CRK, anticorps D-CRK, anticorps D-Crk, anticorps DCrk, anticorps Dcrk, anticorps Dmel\\CG1587, anticorps crk, anticorps dCRK, anticorps dCrk, anticorps fb34h10, anticorps fc05a01, anticorps fi19g05, anticorps wu:fb34h10, anticorps wu:fc05a01, anticorps wu:fc54a04, anticorps wu:fi19g05, anticorps zgc:100936, anticorps CRKII, anticorps p38, anticorps Crko, anticorps crk2, anticorps crkII, anticorps v-crk, anticorps P38C-CRK, anticorps Crk-I, anticorps Crk-II, anticorps Crk-III, anticorps Crk3, anticorps CrkIII, anticorps c-Crk, anticorps Crk oncogene, anticorps v-crk avian sarcoma virus CT10 oncogene homolog, anticorps CRK proto-oncogene, adaptor protein, anticorps v-crk avian sarcoma virus CT10 oncogene homolog L homeolog, anticorps v-crk sarcoma virus CT10 oncogene homolog, anticorps Crk, anticorps crk, anticorps CRK, anticorps crk.L

Sujet:

Description: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Aliases: CRKII

Poids moléculaire: 42kDa

ID gène: 1398

HGNC: 1398

UniProt: P46108

Pathways: Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor