CRTC1 anticorps

N° du produit ABIN969066

Détail du produit anti-CRTC1 anticorps

Antigène: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CRTC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Fonction: CRTC1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human CRTC1 expressed in E. Coli.

Clone: 1B5

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-CRTC1 (ABIN969066)

Heinrich, Böer, Tzvetkov, Oetjen, Knepel: "Stimulation by lithium of the interaction between the transcription factor CREB and its co-activator TORC." dans: Bioscience reports, Vol. 29, Issue 2, pp. 77-87, (2009) (PubMed).

Fehr, Röser, Belge, Löning, Bullerdiek: "A closer look at Warthin tumors and the t(11;19)." dans: Cancer genetics and cytogenetics, Vol. 180, Issue 2, pp. 135-9, (2008) (PubMed).

Winnes, Mölne, Suurküla, Andrén, Persson, Enlund, Stenman: "Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas." dans: Genes, chromosomes & cancer, Vol. 46, Issue 6, pp. 559-63, (2007) (PubMed).

Détails sur CRTC1

Antigène: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Autre désignation: CRTC1 (CRTC1 Produits)

Synonymes: anticorps MECT1, anticorps TORC-1, anticorps TORC1, anticorps WAMTP1, anticorps AI413414, anticorps Mect1, anticorps R74955, anticorps mKIAA0616, anticorps CRTC1, anticorps crtc1, anticorps fc68c05, anticorps pde4cb, anticorps si:ch211-255d18.1, anticorps si:ch211-255d18.8, anticorps wu:fc68c05, anticorps CREB regulated transcription coactivator 1, anticorps CREB regulated transcription coactivator 1b, anticorps CRTC1, anticorps Crtc1, anticorps crtc1, anticorps crtc1b

Sujet:

Description: MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1) functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11,19) (q21,p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein. Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.

Aliases: MECT1, TORC1, WAMTP1, FLJ14027, KIAA0616, CRTC1

Poids moléculaire: 67kDa

ID gène: 23373

HGNC: 23373

UniProt: Q6UUV9