DDR2 anticorps

N° du produit ABIN969083

Détail du produit anti-DDR2 anticorps

Antigène: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DDR2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Fonction: DDR2 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human DDR2 expressed in E. Coli.

Clone: 3B11E4

Isotype: IgG2a

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-DDR2 (ABIN969083)

Leitinger, Kwan: "The discoidin domain receptor DDR2 is a receptor for type X collagen." dans: Matrix biology : journal of the International Society for Matrix Biology, Vol. 25, Issue 6, pp. 355-64, (2006) (PubMed).

Shyu, Chao, Wang, Kuan: "Regulation of discoidin domain receptor 2 by cyclic mechanical stretch in cultured rat vascular smooth muscle cells." dans: Hypertension, Vol. 46, Issue 3, pp. 614-21, (2005) (PubMed).

Neale, Kenny, Gershwin: "Cloning and sequencing of protein kinase cDNA from harbor seal (Phoca vitulina) lymphocytes." dans: Clinical & developmental immunology, Vol. 11, Issue 2, pp. 157-63, (2004) (PubMed).

Détails sur DDR2

Antigène: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Autre désignation: DDR2 (DDR2 Produits)

Synonymes: anticorps MIG20a, anticorps NTRKR3, anticorps TKT, anticorps TYRO10, anticorps AW495251, anticorps Ntrkr3, anticorps tyro10, anticorps DDR2, anticorps Tyro10, anticorps ddr2, anticorps si:ch211-193c2.1, anticorps discoidin domain receptor tyrosine kinase 2, anticorps discoidin domain receptor family, member 2, anticorps discoidin domain receptor family, member 2, like, anticorps DDR2, anticorps Ddr2, anticorps ddr2l

Sujet:

Description: DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Aliases: TKT, MIG20a, NTRKR3, TYRO10

ID gène: 4921

HGNC: 4921

UniProt: Q16832

Pathways: Signalisation RTK