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ErbB2/Her2 anticorps (AA 750-987)

ErbB2/Her2 Reactivité: Humain WB, ELISA, IHC, FACS Hôte: Souris Monoclonal 6C2 unconjugated
N° du produit ABIN969111
  • Antigène Voir toutes ErbB2/Her2 Anticorps
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Épitope
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    AA 750-987
    Reactivité
    • 519
    • 188
    • 166
    • 32
    • 8
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
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    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 410
    • 154
    • 10
    • 6
    • 3
    • 3
    Souris
    Clonalité
    • 416
    • 167
    • 2
    Monoclonal
    Conjugué
    • 269
    • 45
    • 37
    • 28
    • 23
    • 22
    • 10
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    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Cet anticorp ErbB2/Her2 est non-conjugé
    Application
    • 295
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    • 139
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    • 1
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
    Fonction
    ERBB2 Antibody
    Purification
    Ascitic fluid
    Immunogène
    Purified recombinant fragment of human ERBB2(aa750-987) expressed in E. Coli.
    Clone
    6C2
    Isotype
    IgG1
    Top Product
    Discover our top product ErbB2/Her2 Anticorps primaire
  • Indications d'application

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Yamauchi, Stearns, Hayes: "When is a tumor marker ready for prime time? A case study of c-erbB-2 as a predictive factor in breast cancer." dans: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 19, Issue 8, pp. 2334-56, (2001) (PubMed).

  • Antigène
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Autre désignation
    ERBB2 (ErbB2/Her2 Produits)
    Synonymes
    anticorps CD340, anticorps HER-2, anticorps HER-2/neu, anticorps HER2, anticorps MLN 19, anticorps NEU, anticorps NGL, anticorps TKR1, anticorps Erbb-2, anticorps Neu, anticorps c-erbB2, anticorps c-neu, anticorps mKIAA3023, anticorps wu:fv70f10, anticorps zgc:63601, anticorps erb2, anticorps erb-b2 receptor tyrosine kinase 2, anticorps ERBB2, anticorps Erbb2, anticorps erbb2
    Sujet

    Description: ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian). This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

    Aliases: NEU, HER2, TKR1, CD340, HER-2

    Poids moléculaire
    180kDa
    ID gène
    2064
    HGNC
    2064
    UniProt
    P04626
    Pathways
    Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
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