ETV4 anticorps (AA 50-109)

N° du produit ABIN969121

Détail du produit anti-ETV4 anticorps

Antigène: ETV4 (Ets Variant 4 (ETV4))

Épitope: AA 50-109

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ETV4 est non-conjugé

Application: ELISA

Fonction: ETV4 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human ETV4 (aa50-109) expressed in E. Coli.

Clone: 1A2G3

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-ETV4 (ABIN969121)

Yu, Xia, Wang, Wang, Pan, Kwong, Hortobagyi, Hung: "Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1." dans: Molecular carcinogenesis, Vol. 45, Issue 9, pp. 667-75, (2006) (PubMed).

Matsui, Sugimori, Motomura, Ejiri, Tsukada, Kitajima: "PEA3 cooperates with c-Jun in regulation of HER2/neu transcription." dans: Oncology reports, Vol. 16, Issue 1, pp. 153-8, (2006) (PubMed).

Zhu, Jiang, Shen, Wang, Zong, Li, Yang, Niu, Liu, Chen, Hu, Gu: "Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator." dans: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 12503-16, (2005) (PubMed).

Détails sur ETV4

Antigène: ETV4 (Ets Variant 4 (ETV4))

Autre désignation: ETV4 (ETV4 Produits)

Synonymes: anticorps E1A-F, anticorps E1AF, anticorps PEA3, anticorps PEAS3, anticorps Pea3, anticorps AW414408, anticorps Pea-3, anticorps pea3, anticorps ETS variant 4, anticorps ets variant 4, anticorps ETV4, anticorps Etv4, anticorps etv4

Sujet:

Description: ETV4: ets variant gene 4 (E1A enhancer binding protein, E1AF), also known as PEA3. Several members of the Ets gene family are known to encode sequencespecific DNA binding proteins. These include mouse PU.1, mouse and human Ets-1, Drosophila E74, chicken and human Ets-2 and rat GABP-a. Each of these proteins recognizes similar motifs in DNA that share a centrally located 5'-GGAA-3' element. For instance, PEA3 binds the motif 5'-AGGAAG-3' (the PEA-3 motif), but does not bind to the sequence 5'-AGGAAC-3', recognized by PU.1, although PU.1 binds equally well to both sequences. It appears that all of the Ets proteins recognize the same central core sequence but that each protein interacts with unique sequences that flank this core. PEA3 is expressed at readily detectable levels in cells of epithelial and fibroblastic origin but is not expressed in hematopoietic cells. This is in contrast to other members of the Ets gene family, such as Ets-1, Ets-2 and Fli-1, each of which is expressed primarily in cells of hematopoietic origin.

Aliases: HGK, NIK, PEA3

Poids moléculaire: 54kDa

ID gène: 2118

HGNC: 2118

UniProt: P43268