FAK anticorps

N° du produit ABIN969130

Détail du produit anti-FAK anticorps

Antigène: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FAK est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Fonction: FAK Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human FAK expressed in E. Coli.

Clone: 10H7

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-FAK (ABIN969130)

Toutant, Costa, Studler, Kadaré, Carnaud, Girault: "Alternative splicing controls the mechanisms of FAK autophosphorylation." dans: Molecular and cellular biology, Vol. 22, Issue 22, pp. 7731-43, (2002) (PubMed).

Huang, Cheung, Parsons, Bryer-Ash: "Focal adhesion kinase (FAK) regulates insulin-stimulated glycogen synthesis in hepatocytes." dans: The Journal of biological chemistry, Vol. 277, Issue 20, pp. 18151-60, (2002) (PubMed).

Détails sur FAK

Antigène: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Autre désignation: FAK (PTK2 Produits)

Synonymes: anticorps FADK, anticorps FAK, anticorps FAK1, anticorps FRNK, anticorps PPP1R71, anticorps p125FAK, anticorps pp125FAK, anticorps PTK2, anticorps Fadk, anticorps mKIAA4203, anticorps fak, anticorps fak1a, anticorps ptk2, anticorps ptk2a, anticorps wu:fa18c04, anticorps zgc:66114, anticorps CG10023, anticorps CT28129, anticorps DFAK, anticorps DFak, anticorps DFak56, anticorps Dfak, anticorps Dfak56, anticorps DmFAK, anticorps Dmel\\CG10023, anticorps Fak56, anticorps Fak56D, anticorps fak56, anticorps protein tyrosine kinase 2, anticorps protein tyrosine kinase 2 L homeolog, anticorps PTK2 protein tyrosine kinase 2, anticorps protein tyrosine kinase 2ab, anticorps Focal adhesion kinase, anticorps PTK2, anticorps ptk2.L, anticorps Ptk2, anticorps ptk2ab, anticorps Fak

Sujet:

Description: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined. Tissue specificity: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.RD: Focal adhesion kinase 1 (FAK) is a ubiquitously expressed non-receptor protein tyrosine kinase that is concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. This cellular localization is directed by a

Aliases: FAK, FADK, FAK1, FRNK, pp125FAK, PTK2

Poids moléculaire: 119kDa

ID gène: 5747

HGNC: 5747

UniProt: Q05397

Pathways: Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling