FGFR1 anticorps (AA 22-376)

N° du produit ABIN969138

Détail du produit anti-FGFR1 anticorps

Antigène: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Épitope: AA 22-376

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FGFR1 est non-conjugé

Application: ELISA

Fonction: FGFR1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant extracellular fragment of human FGFR1 (aa22-376) fused with hIgGFc tag expressed in HEK293 cells.

Clone: 3D4F7

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-FGFR1 (ABIN969138)

Elbauomy Elsheikh, Green, Lambros, Turner, Grainge, Powe, Ellis, Reis-Filho: "FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis." dans: Breast cancer research : BCR, Vol. 9, Issue 2, pp. R23, (2007) (PubMed).

Magnusson, Ronca, DellEra, Carlstedt, Jakobsson, Partanen, Dimberg, Claesson-Welsh: "Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development." dans: Arteriosclerosis, thrombosis, and vascular biology, Vol. 25, Issue 5, pp. 944-9, (2005) (PubMed).

Hu, Fang, Dunham, Prada, Stachowiak, Stachowiak: "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling." dans: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 29325-35, (2004) (PubMed).

Détails sur FGFR1

Antigène: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Autre désignation: FGFR1 (FGFR1 Produits)

Sujet:

Description: Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome. It is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction.

Aliases: CEK, FLG, OGD, FLT2, KAL2, BFGFR, CD331, FGFBR, HBGFR

Poids moléculaire: 92kDa

ID gène: 2260

HGNC: 2260

UniProt: P11362

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins