FOXD3 anticorps

N° du produit ABIN969152

Il existe 1 publication pour ce produit. L’anticorps anti-FOXD3 Monoclonal Souris est utilisé pour la détection de FOXD3 dans des échantillons de Humain, Souris et Singe. Il a été validé pour WB et ELISA.

Aperçu rapide pour FOXD3 anticorps (ABIN969152)

Antigène: FOXD3 (Forkhead Box D3 (FOXD3))

Reactivité: Humain, Souris, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FOXD3 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 5G9

Détail du produit anti-FOXD3 anticorps

Fonction: FOXD3 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human FOXD3 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-FOXD3 (ABIN969152)

Saleem, Banerjee-Basu, Berry, Baxevanis, Walter: "Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1." dans: American journal of human genetics, Vol. 68, Issue 3, pp. 627-41, (2001) (PubMed).

Détails sur FOXD3

Antigène: FOXD3 (Forkhead Box D3 (FOXD3))

Autre désignation: FOXD3

Sujet: FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development . This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation . FoxD3 is required for the maintenance of the mammalian neural crest, FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures . FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells .Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis .Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined .

Poids moléculaire: 48 kDa

UniProt: Q9UJU5