Glucagon anticorps

N° du produit ABIN969171

Détail du produit anti-Glucagon anticorps

Antigène: Glucagon (GCG)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Glucagon est non-conjugé

Application: ELISA

Fonction: GCG Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human GCG expressed in E. Coli.

Clone: 2F9

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Glucagon (ABIN969171)

Arnés, González, Tornero-Esteban, Sancho, Acitores, Valverde, Delgado, Villanueva-Peñacarrillo: "Characteristics of GLP-1 and exendins action upon glucose transport and metabolism in type 2 diabetic rat skeletal muscle." dans: International journal of molecular medicine, Vol. 22, Issue 1, pp. 127-32, (2008) (PubMed).

Détails sur Glucagon

Antigène: Glucagon (GCG)

Autre désignation: GCG (GCG Produits)

Sujet:

Description: The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.Tissue specificity: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.

Aliases: GLP1, GLP2, GRPP, GCG

Poids moléculaire: 21kDa

ID gène: 2641

HGNC: 2641

UniProt: P01275

Pathways: Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Negative Regulation of intrinsic apoptotic Signaling