GPI anticorps

N° du produit ABIN969176

Détail du produit anti-GPI anticorps

Antigène: GPI (Glucose-6-Phosphate Isomerase (GPI))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GPI est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Fonction: Glucose-6-phosphate isomerase Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human GPI expressed in E. Coli.

Clone: 1B7D7

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-GPI (ABIN969176)

Schaller, Stohl, Benoit, Tan, Johansen, Ditzel: "Patients with inflammatory arthritic diseases harbor elevated serum and synovial fluid levels of free and immune-complexed glucose-6-phosphate isomerase (G6PI)." dans: Biochemical and biophysical research communications, Vol. 349, Issue 2, pp. 838-45, (2006) (PubMed).

Haga, Komazaki, Funasaka, Hashimoto, Yokoyama, Watanabe, Raz, Nagase: "AMF/G6PI induces differentiation of leukemic cells via an unknown receptor that differs from gp78." dans: Leukemia & lymphoma, Vol. 47, Issue 10, pp. 2234-43, (2006) (PubMed).

Muraki, Matsumoto, Chino, Hayashi, Suzuki, Goto, Ito, Murata, Tsutsumi, Sumida: "Glucose-6-phosphate isomerase variants play a key role in the generation of anti-GPI antibodies: possible mechanism of autoantibody production." dans: Biochemical and biophysical research communications, Vol. 323, Issue 2, pp. 518-22, (2004) (PubMed).

Détails sur GPI

Antigène: GPI (Glucose-6-Phosphate Isomerase (GPI))

Autre désignation: Glucose-6-phosphate isomerase (GPI Produits)

Synonymes: anticorps PGI, anticorps Amf, anticorps Gpi1, anticorps GPI, anticorps DDBDRAFT_0185620, anticorps DDBDRAFT_0231026, anticorps DDB_0185620, anticorps DDB_0231026, anticorps CG8251, anticorps Dmel\\CG8251, anticorps Gpi, anticorps pgi, anticorps Gpi-1, anticorps Gpi-1r, anticorps Gpi-1s, anticorps Gpi-1t, anticorps Gpi1-r, anticorps Gpi1-s, anticorps Gpi1-t, anticorps Gpi1s, anticorps MF, anticorps NK, anticorps NK/GPI, anticorps Org, anticorps AMF, anticorps GNPI, anticorps NLK, anticorps PHI, anticorps SA-36, anticorps SA36, anticorps gpi, anticorps pgi-2, anticorps glucose-6-phosphate isomerase, anticorps gpi, anticorps glucose-6-phosphate isomerase 1, anticorps gpi Glucose-6-phosphate isomerase, anticorps Phosphoglucose isomerase, anticorps glucose phosphate isomerase 1, anticorps glucose-6-phosphate isomerase b, anticorps GPI, anticorps Gpi, anticorps gpi, anticorps pgi, anticorps GPI1, anticorps Pgi, anticorps Gpi1, anticorps gpib

Classe de substances: Viral Protein

Sujet:

Description: Glucose-6-phosphate isomerase, or phosphoglucose isomerase, also known as GPI. It belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways and it is an enzyme that catalyzes the conversion of glucose-6-phosphate into fructose 6-phosphate in the second step of glycolysis. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in GPI are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.

Aliases: AMF, NLK, PGI, PHI, GNPI, SA-36, GPI

Poids moléculaire: 63kDa

ID gène: 2821

HGNC: 2821

UniProt: P06744