GRK2 anticorps
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- Antigène Voir toutes GRK2 (ADRBK1) Anticorps
- GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
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Reactivité
- Humain, Souris, Rat, Singe
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp GRK2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)
- Purification
- purified
- Immunogène
- Purified recombinant fragment of human GRK2 expressed in E. coli.
- Clone
- 3F8
- Isotype
- IgG1
- Top Product
- Discover our top product ADRBK1 Anticorps primaire
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- Indications d'application
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- 4°C, -20°C for long term storage
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GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail." dans: Biochemistry, Vol. 48, Issue 20, pp. 4285-93, (2009) (PubMed).
: "EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation." dans: Molecular biology of the cell, Vol. 19, Issue 7, pp. 2973-83, (2008) (PubMed).
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GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail." dans: Biochemistry, Vol. 48, Issue 20, pp. 4285-93, (2009) (PubMed).
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- Antigène
- GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
- Autre désignation
- GRK2 (ADRBK1 Produits)
- Synonymes
- anticorps Adrbk-1, anticorps Bark-1, anticorps GRK2, anticorps betaARK1, anticorps BARK1, anticorps BETA-ARK1, anticorps GRK-2, anticorps Grk2, anticorps beta-adrenergic receptor kinase 1, anticorps G protein-coupled receptor kinase 2, anticorps Tsp_00497, anticorps grk2, anticorps Grk2, anticorps GRK2
- Sujet
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Description: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. (provided by RefSeq)Tissue specificity: Expressed in peripheral blood leukocytes
Aliases: GRK2, BARK1, FLJ16718, BETA-ARK1, ADRBK1
- Poids moléculaire
- 80 kDa
- ID gène
- 156
- HGNC
- 156
- Pathways
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling
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