HAS1 anticorps

N° du produit ABIN969185

Détail du produit anti-HAS1 anticorps

Antigène: HAS1 (Hyaluronan Synthase 1 (HAS1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HAS1 est non-conjugé

Application: ELISA, Immunocytochemistry (ICC)

Fonction: HAS1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human HAS1 expressed in E. Coli.

Clone: 3E10

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-HAS1 (ABIN969185)

Stuhlmeier: "Hyaluronan production in synoviocytes as a consequence of viral infections: HAS1 activation by Epstein-Barr virus and synthetic double- and single-stranded viral RNA analogs." dans: The Journal of biological chemistry, Vol. 283, Issue 24, pp. 16781-9, (2008) (PubMed).

Adamia, Treon, Reiman, Tournilhac, McQuarrie, Mant, Belch, Pilarski: "Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia." dans: Clinical lymphoma, Vol. 5, Issue 4, pp. 253-6, (2005) (PubMed).

Détails sur HAS1

Antigène: HAS1 (Hyaluronan Synthase 1 (HAS1))

Autre désignation: HAS1 (HAS1 Produits)

Synonymes: anticorps dg42, anticorps Xhas1, anticorps HAS, anticorps shas1, anticorps hyaluronan synthase 1, anticorps hyaluronan synthase 1 S homeolog, anticorps has1, anticorps HAS1, anticorps Has1, anticorps has1.S

Sujet:

Description: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.

Aliases: HAS, HAS1

Poids moléculaire: 65kDa

ID gène: 3036

HGNC: 3036

UniProt: Q92839

Pathways: Glycosaminoglycan Metabolic Process