Hexokinase 2 anticorps

N° du produit ABIN969196

Détail du produit anti-Hexokinase 2 anticorps

Antigène: Hexokinase 2 (HK2)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Hexokinase 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Fonction: HK2 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human HK2 expressed in E. Coli.

Clone: 3D3

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Hexokinase 2 (ABIN969196)

He, Bi, Zheng, Dai, Han, Liang, Ye, Zeng, Zhu, Zhong: "Real-time quantitative RT-PCR assessment of PIM-1 and hK2 mRNA expression in benign prostate hyperplasia and prostate cancer." dans: Medical oncology (Northwood, London, England), Vol. 26, Issue 3, pp. 303-8, (2009) (PubMed).

Paudyal, Oriuchi, Paudyal, Higuchi, Nakajima, Endo: "Expression of glucose transporters and hexokinase II in cholangiocellular carcinoma compared using [18F]-2-fluro-2-deoxy-D-glucose positron emission tomography." dans: Cancer science, Vol. 99, Issue 2, pp. 260-6, (2008) (PubMed).

Lim, Hao, Shaw, Patel, Szabó, Rual, Fisk, Li, Smolyar, Hill, Barabási, Vidal, Zoghbi: "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration." dans: Cell, Vol. 125, Issue 4, pp. 801-14, (2006) (PubMed).

Détails sur Hexokinase 2

Antigène: Hexokinase 2 (HK2)

Autre désignation: HK2 (HK2 Produits)

Synonymes: anticorps HKII, anticorps HXK2, anticorps AI642394, anticorps hexokinase-2, anticorps fi09d05, anticorps fi17h06, anticorps wu:fi09d05, anticorps wu:fi17h06, anticorps wu:fi31b04, anticorps zgc:55926, anticorps HK2, anticorps ARABIDOPSIS THALIANA HEXOKINASE 2, anticorps ATHXK2, anticorps F6F22.11, anticorps F6F22_11, anticorps HEXOKINASE 2, anticorps hexokinase 2, anticorps StHK2, anticorps hexokinase 2, anticorps hexokinase-2, anticorps hexokinase 2 L homeolog, anticorps HK2, anticorps Hk2, anticorps hk2, anticorps HXK2, anticorps LOC100032849, anticorps hk2.L, anticorps hxk2, anticorps LOC102577690

Sujet:

Description: The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose- 6-phosphate. Four hexokinase isoenzymes have been identified, including hexokinase I (HXK I), hexokinase II (HXK II), hexokinase III (HXK III) and hexokinase IV (HXK IV, also designated glucokinase or GCK). Hexokinases I-III each contain an N-terminal cluster of hydrophobic amino acids. Glucokinase lacks the N-terminal hydrophobic cluster. The hydrophobic cluster is thought to be necessary for membrane binding. This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other hexokinases .Hexokinase 2 is the predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

Aliases: HKII, HXK2, DKFZp686M1669, HK2

Poids moléculaire: 102kDa

ID gène: 3099

HGNC: 3099

UniProt: P52789

Pathways: Signalisation PI3K-Akt, Carbohydrate Homeostasis, L'effet Warburg