ITGA5 anticorps

N° du produit ABIN969221

Détail du produit anti-ITGA5 anticorps

Antigène: ITGA5 (Integrin, alpha 5 (ITGA5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ITGA5 est non-conjugé

Application: Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)

Fonction: ITGA5 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human ITGA5 expressed in E. Coli.

Clone: 10F6

Isotype: IgG2a

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-ITGA5 (ABIN969221)

Mould, Askari, Barton, Kline, McEwan, Craig, Humphries: "Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain." dans: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19800-5, (2002) (PubMed).

Zhao, Newman: "Integrin activation by regulated dimerization and oligomerization of platelet endothelial cell adhesion molecule (PECAM)-1 from within the cell." dans: The Journal of cell biology, Vol. 152, Issue 1, pp. 65-73, (2001) (PubMed).

Wong, Wiedle, Ballestrem, Wehrle-Haller, Etteldorf, Bruckner, Engelhardt, Gisler, Imhof: "PECAM-1/CD31 trans-homophilic binding at the intercellular junctions is independent of its cytoplasmic domain; evidence for heterophilic interaction with integrin alphavbeta3 in Cis." dans: Molecular biology of the cell, Vol. 11, Issue 9, pp. 3109-21, (2000) (PubMed).

Détails sur ITGA5

Antigène: ITGA5 (Integrin, alpha 5 (ITGA5))

Autre désignation: ITGA5 (ITGA5 Produits)

Sujet:

Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.

Aliases: FNRA, CD49e, VLA5A, ITGA5

Poids moléculaire: 114kDa

ID gène: 3678

HGNC: 3678

UniProt: P08648

Pathways: Integrin Complex