KDM3A anticorps

N° du produit ABIN969229

Détail du produit anti-KDM3A anticorps

Antigène: KDM3A (Lysine (K)-Specific Demethylase 3A (KDM3A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KDM3A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Fonction: KDM3A Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human KDM3A expressed in E. Coli.

Clone: 2E1

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-KDM3A (ABIN969229)

Sobral, Sechler, Parrish, McCann, Jones, Black, Jedlicka: "KDM3A/Ets1/MCAM axis promotes growth and metastatic properties in Rhabdomyosarcoma." dans: Genes & cancer, Vol. 11, Issue 1-2, pp. 53-65, (2020) (PubMed).

Sechler, Parrish, Birks, Jedlicka: "The histone demethylase KDM3A, and its downstream target MCAM, promote Ewing Sarcoma cell migration and metastasis." dans: Oncogene, Vol. 36, Issue 29, pp. 4150-4160, (2017) (PubMed).

Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." dans: Nature, Vol. 434, Issue 7034, pp. 724-31, (2005) (PubMed).

Nagase, Ishikawa, Suyama, Kikuno, Miyajima, Tanaka, Kotani, Nomura, Ohara: "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." dans: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 5, Issue 5, pp. 277-86, (1999) (PubMed).

Détails sur KDM3A

Antigène: KDM3A (Lysine (K)-Specific Demethylase 3A (KDM3A))

Autre désignation: KDM3A (KDM3A Produits)

Synonymes: anticorps JHDM2A, anticorps JHMD2A, anticorps JMJD1, anticorps JMJD1A, anticorps TSGA, anticorps tsga, anticorps jmjd1, anticorps jhdm2a, anticorps jhmd2a, anticorps jmjd1a, anticorps 1700105C21Rik, anticorps C230043E16Rik, anticorps JHDM2a, anticorps Jmjd1, anticorps Jmjd1a, anticorps KDM2A, anticorps TGSA, anticorps Tsga, anticorps mKIAA0742, anticorps KDM3A, anticorps kdm3a, anticorps lysine demethylase 3A, anticorps lysine (K)-specific demethylase 3A, anticorps lysine-specific demethylase 3A, anticorps lysine (K)-specific demethylase 3A S homeolog, anticorps KDM3A, anticorps kdm3a, anticorps Kdm3a, anticorps LOC100453519, anticorps kdm3a.S

Sujet:

Description: This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and alpha-ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.

Aliases: TSGA, JMJD1, JHDM2A, JHMD2A, JMJD1A, KIAA0742, DKFZp686A24246, DKFZp686P07111, KDM3A

Poids moléculaire: 147kDa

ID gène: 55818

HGNC: 55818

UniProt: Q9Y4C1

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, L'effet Warburg