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VEGFR2/CD309 anticorps (AA 20-764)

Name: VEGFR2/CD309 anticorps (AA 20-764)
Brand: antibodies-online
SKU: ABIN969231
Price: 587.53 EUR
Availability: InStock

VEGFR2 Reactivité: Humain ELISA, FACS, ICC Hôte: Souris Monoclonal 4B4 unconjugated

Western blot analysis using KDR mouse mAb against extracellular domain of human KDR (aa20-764). (VEGFR2/CD309 anticorps (AA 20-764))

Flow cytometric analysis of HepG2 cells using KDR mouse mAb (green) and negative control (purple). (VEGFR2/CD309 anticorps (AA 20-764))

FACS

Confocal immunofluorescence analysis of Hela (left) and HepG2 (right) cells using KDR mouse mAb (green). (VEGFR2/CD309 anticorps (AA 20-764))

3 images

(1 reference)

N° du produit ABIN969231

Fiche de données

Antigène Voir toutes VEGFR2/CD309 (VEGFR2) Anticorps

VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
Épitope
37

34

27

23

20

16

11

10

9

8

8

6

5

5

5

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 20-764
Reactivité
290

183

128

9

5

3

3

3

3

1

1

1

1

1

1

1

1

1

1

1
Humain
Hôte
273

58

23

1

1
Souris
Anticorps secondaires appropriés
Clonalité
265

91
Monoclonal
Conjugué
161

30

18

13

10

9

9

7

7

7

7

7

5

5

5

5

5

5

5

5

5

5

5

3

2

2

2

1

1

1

1

1

1

1
Cet anticorp VEGFR2/CD309 est non-conjugé
Application
212

116

98

81

64

25

24

17

13

13

11

9

7

7

7

4

2

2

2

2

2

1

1

1
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Fonction

KDR Antibody

Purification

Ascitic fluid

Immunogène

Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.

Clone

4B4

Isotype

IgG1

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Indications d'application

ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000

Restrictions

For Research Use only
Format

Liquid

Buffer

Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

4 °C,-20 °C

Stockage commentaire

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Takahashi, Yamaguchi, Chida, Shibuya: "A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells." dans: The EMBO journal, Vol. 20, Issue 11, pp. 2768-78, (2001) (PubMed).
Antigène

VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Autre désignation

KDR (VEGFR2 Produits)

Sujet

Description: KDR has also been designated as VEFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
Aliases: FLK1, CD309, VEGFR, VEGFR2

Poids moléculaire

152kDa

ID gène

3791

HGNC

3791

UniProt

P35968

Pathways

Signalisation RTK, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling