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KLHL13 anticorps

KLHL13 Reactivité: Humain WB, ELISA, IHC, FACS, ICC Hôte: Souris Monoclonal 8D1 unconjugated
N° du produit ABIN969245
  • Antigène Voir toutes KLHL13 Anticorps
    KLHL13 (Kelch-Like 13 (KLHL13))
    Reactivité
    • 16
    • 15
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 23
    • 8
    Souris
    Clonalité
    • 23
    • 8
    Monoclonal
    Conjugué
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp KLHL13 est non-conjugé
    Application
    • 24
    • 13
    • 13
    • 7
    • 6
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Fonction
    KLHL13 Antibody
    Purification
    Ascitic fluid
    Immunogène
    Purified recombinant fragment of human KLHL13 expressed in E. Coli.
    Clone
    8D1
    Isotype
    IgG1
  • Indications d'application

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/200 - 1/1000

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Jin, Pahuja, Wickliffe, Gorur, Baumgärtel, Schekman, Rape: "Ubiquitin-dependent regulation of COPII coat size and function." dans: Nature, Vol. 482, Issue 7386, pp. 495-500, (2012) (PubMed).

    Suzuki, Yamashita, Shirota, Sakakibara, Chiba, Mizushima-Sugano, Nakai, Sugano: "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions." dans: Genome research, Vol. 14, Issue 9, pp. 1711-8, (2004) (PubMed).

  • Antigène
    KLHL13 (Kelch-Like 13 (KLHL13))
    Autre désignation
    KLHL13 (KLHL13 Produits)
    Synonymes
    anticorps 1200009K10Rik, anticorps AI451128, anticorps Bklhd2, anticorps D130072F20Rik, anticorps mKIAA1309, anticorps BKLHD2, anticorps Kelch-like protein 13, anticorps kelch-like 13, anticorps kelch like family member 13, anticorps kelch like family member 9, anticorps kelch-like family member 13, anticorps klh13, anticorps Klhl13, anticorps KLHL13, anticorps KLHL9
    Sujet

    Description: KLHL13 (kelch-like 13), also known as BKLHD2 (BTB and kelch domain-containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate- specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Via its BTB and C-terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL-3 ligase.

    Aliases: BKLHD2, FLJ10262, MGC74791, KLHL13

    Poids moléculaire
    74kDa
    ID gène
    90293
    HGNC
    90293
    UniProt
    Q9P2N7
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