LYN anticorps
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- Antigène Voir toutes LYN Anticorps
- LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp LYN est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Purification
- purified
- Immunogène
- Purified recombinant fragment of LYN expressed in E. coli.
- Clone
- 2H8D7
- Isotype
- IgG2b
- Top Product
- Discover our top product LYN Anticorps primaire
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- Indications d'application
- ELISA: 1:10000, WB: 1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- 4°C, -20°C for long term storage
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- Antigène
- LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
- Autre désignation
- LYN (LYN Produits)
- Synonymes
- anticorps JTK8, anticorps p53Lyn, anticorps p56Lyn, anticorps lyn, anticorps LYN, anticorps AA407514, anticorps Hck-2, anticorps jtk8, anticorps lyn-A, anticorps CH73-38P6.3, anticorps zgc:92124, anticorps LYN proto-oncogene, Src family tyrosine kinase, anticorps v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, anticorps tyrosine-protein kinase Lyn, anticorps LYN proto-oncogene, Src family tyrosine kinase L homeolog, anticorps LYN, anticorps lyn, anticorps Lyn, anticorps LOC100593961, anticorps lyn.L
- Sujet
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Description: Lyn (also known as p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphor-ylate Tec on multiple residues. Lyn can also be regulated by IL-2 and IL-3.Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI).
Aliases: JTK8, FLJ26625
- Poids moléculaire
- 56 kDa
- ID gène
- 4067
- HGNC
- 4067
- Pathways
- Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling
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