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MUSK anticorps (AA 24-209)

MUSK Reactivité: Humain ELISA, IHC, ICC Hôte: Souris Monoclonal 10A4 unconjugated
N° du produit ABIN969299
  • Antigène Voir toutes MUSK Anticorps
    MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))
    Épitope
    • 15
    • 10
    • 8
    • 8
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 24-209
    Reactivité
    • 72
    • 29
    • 25
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 67
    • 7
    • 2
    Souris
    Clonalité
    • 72
    • 7
    Monoclonal
    Conjugué
    • 39
    • 5
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MUSK est non-conjugé
    Application
    • 67
    • 34
    • 29
    • 14
    • 13
    • 13
    • 11
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Purification
    purified
    Immunogène
    Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.
    Clone
    10A4
    Isotype
    IgG1
    Top Product
    Discover our top product MUSK Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Boneva, Frenkian-Cuvelier, Bidault, Brenner, Berrih-Aknin: "Major pathogenic effects of anti-MuSK antibodies in myasthenia gravis." dans: Journal of neuroimmunology, Vol. 177, Issue 1-2, pp. 119-31, (2006) (PubMed).

  • Antigène
    MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))
    Autre désignation
    MUSK (MUSK Produits)
    Synonymes
    anticorps unp, anticorps fj98e12, anticorps zgc:63467, anticorps wu:fj98e12, anticorps si:dz46m7.2, anticorps si:dz57f23.3, anticorps si:busm1-57f23.3, anticorps musk-A, anticorps MuSK, anticorps MUSK, anticorps Mdk4, anticorps Mlk, anticorps Nsk1, anticorps Nsk2, anticorps Nsk3, anticorps muscle, anticorps muscle associated receptor tyrosine kinase, anticorps muscle, skeletal, receptor tyrosine kinase, anticorps muscle associated receptor tyrosine kinase S homeolog, anticorps MUSK, anticorps musk, anticorps musk.S, anticorps Musk
    Sujet

    Description: MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.

    Aliases: muscle, skeletal, receptor tyrosine kinase

    Poids moléculaire
    97 kDa
    ID gène
    4593
    HGNC
    4593
    Pathways
    Signalisation RTK, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development
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