NGFR anticorps

N° du produit ABIN969315

Détail du produit anti-NGFR anticorps

Antigène: NGFR (Nerve Growth Factor Receptor (NGFR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NGFR est non-conjugé

Application: Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC)

Fonction: NGFR Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human NGFR expressed in E. Coli.

Clone: 2F1C2

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-NGFR (ABIN969315)

He, Garcia: "Structure of nerve growth factor complexed with the shared neurotrophin receptor p75." dans: Science (New York, N.Y.), Vol. 304, Issue 5672, pp. 870-5, (2004) (PubMed).

Hu, Zhang, Qin, Xu, Swaab, Zhou: "Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients." dans: Experimental neurology, Vol. 178, Issue 1, pp. 104-11, (2002) (PubMed).

Détails sur NGFR

Antigène: NGFR (Nerve Growth Factor Receptor (NGFR))

Autre désignation: NGFR (NGFR Produits)

Sujet:

Description: Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to NGFR p75 activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).

Aliases: CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, NGFR

Poids moléculaire: 45kDa

ID gène: 4804

HGNC: 4804

UniProt: P08138

Pathways: Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding