NQO1 anticorps

N° du produit ABIN969319

Détail du produit anti-NQO1 anticorps

Antigène: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NQO1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Fonction: NQO1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human NQO1 expressed in E. Coli.

Clone: 4D12

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-NQO1 (ABIN969319)

Kansanen, Jyrkkänen, Volger, Leinonen, Kivelä, Häkkinen, Woodcock, Schopfer, Horrevoets, Ylä-Herttuala, Freeman, Levonen: "Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid." dans: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33233-41, (2009) (PubMed).

Douglas, Lim, Porter, West, Pink, Ge, Wylie, Tibbits, Biggs, Curtis, Palombella, Adams, Fritz, Normant: "The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo." dans: Molecular cancer therapeutics, Vol. 8, Issue 12, pp. 3369-78, (2009) (PubMed).

Détails sur NQO1

Antigène: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Autre désignation: NQO1 (NQO1 Produits)

Synonymes: anticorps zgc:77191, anticorps wu:fb63c10, anticorps nqo1, anticorps DHQU, anticorps DIA4, anticorps DTD, anticorps NMOR1, anticorps NMORI, anticorps QR1, anticorps Dia4, anticorps AV001255, anticorps Dtd, anticorps Nmo-1, anticorps Nmo1, anticorps Nmor1, anticorps Ox-1, anticorps Ox1, anticorps Qr1, anticorps NADPH-d, anticorps NAD(P)H dehydrogenase, quinone 1, anticorps NAD(P)H quinone dehydrogenase 1, anticorps NAD(P)H dehydrogenase, quinone 1 L homeolog, anticorps nqo1, anticorps NQO1, anticorps Bpet2092, anticorps nqo1.L, anticorps Nqo1

Sujet:

Description: This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Aliases: DTD, QR1, DHQU, DIA4, NMOR1, NMORI

Poids moléculaire: 31kDa

ID gène: 1728

HGNC: 1728

UniProt: P15559