PAX6 anticorps

N° du produit ABIN969342

Détail du produit anti-PAX6 anticorps

Antigène: PAX6 (Paired Box 6 (PAX6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAX6 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purification: purified

Immunogène: Purified recombinant fragment of human PAX6 expressed in E. coli.

Clone: 1C8

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-PAX6 (ABIN969342)

Zhang, Yamada, Fan, Bangaru, Lin, Yang: "The beta subunit of voltage-gated Ca2+ channels interacts with and regulates the activity of a novel isoform of Pax6." dans: The Journal of biological chemistry, Vol. 285, Issue 4, pp. 2527-36, (2010) (PubMed).

Hingorani, Williamson, Moore, van Heyningen: "Detailed ophthalmologic evaluation of 43 individuals with PAX6 mutations." dans: Investigative ophthalmology & visual science, Vol. 50, Issue 6, pp. 2581-90, (2009) (PubMed).

Mascarenhas, Young, Littlejohn, Yoo, Salgia, Lang: "PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene." dans: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27524-32, (2009) (PubMed).

Détails sur PAX6

Antigène: PAX6 (Paired Box 6 (PAX6))

Autre désignation: PAX6 (PAX6 Produits)

Synonymes: anticorps pax6, anticorps an2, anticorps mgda, anticorps wagr, anticorps pax-6, anticorps pax6a, anticorps xpax6, anticorps XLPAX6, anticorps MGC52531, anticorps PAX-6, anticorps AN, anticorps AN2, anticorps D11S812E, anticorps MGDA, anticorps WAGR, anticorps Pax-6, anticorps pax6b, anticorps 1500038E17Rik, anticorps AEY11, anticorps Dey, anticorps Gsfaey11, anticorps Sey, anticorps PAXZF-A, anticorps Pax6.1, anticorps cb280, anticorps fc20e07, anticorps pax-a, anticorps pax[zf-a], anticorps paxzfa, anticorps wu:fc20e07, anticorps zfpax-6a, anticorps zfpax-6b, anticorps paired box 6, anticorps paired box 6 L homeolog, anticorps paired box 6 S homeolog, anticorps paired box 6a, anticorps PAX6, anticorps pax6, anticorps Pax6, anticorps pax6.L, anticorps pax6.S, anticorps pax6a

Sujet:

Description: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells .PAX6 is the most researched of the PAX genes and appears throughout the literature as a "master control" gene for the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other homologous structures, usually derived from ectodermal tissues. This transcription factor is most famous for its use in the interspecifically induced expression of ectopic eyes and is of medical importance because heterozygous mutants produce a wide spectrum of ocular defects such as Aniridia in humans. This gene encodes paired box gene 6, one of many human homologues of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause aniridia as well as Peter's anomaly, both ocular diseases.

Aliases: AN, AN2, MGDA, WAGR, D11S812E, MGC17209, PAX6

Poids moléculaire: 46 kDa

ID gène: 5080

HGNC: 5080

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis