PEG10 anticorps

N° du produit ABIN969349

Cet anticorps Souris Monoclonal détecte spécifiquement PEG10 dans ELISA et IHC. Il présente une réactivité avec des échantillons de Humain. Il a été cité dans 3+ publications.

Aperçu rapide pour PEG10 anticorps (ABIN969349)

Antigène: PEG10 (Paternally Expressed 10 (PEG10))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PEG10 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Clone: 4C10A7

Détail du produit anti-PEG10 anticorps

Fonction: PEG10 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human PEG10 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-PEG10 (ABIN969349)

Kochetov, Ahmad, Ivanisenko, Volkova, Kolchanov, Sarai: "uORFs, reinitiation and alternative translation start sites in human mRNAs." dans: FEBS letters, Vol. 582, Issue 9, pp. 1293-7, (2008) (PubMed).

Wang, Xiao, Hu, Chen, Liu, Hu: "PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma." dans: FEBS letters, Vol. 582, Issue 18, pp. 2793-8, (2008) (PubMed).

Jie, Lang, Jian, Chaoqun, Dehua, Yi, Yanping, Luokun, Qiuping, Hui, Feili, Boquan, Youxin, Jinquan: "Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells." dans: Oncogene, Vol. 26, Issue 39, pp. 5741-51, (2007) (PubMed).

Détails sur PEG10

Antigène: PEG10 (Paternally Expressed 10 (PEG10))

Autre désignation: PEG10

Sujet: PEG10, paternally expressed 10. The PEG10 includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.

Poids moléculaire: Isoform RF1 (37 kDa), RF1/RF2 (80 kDa)

UniProt: Q86TG7