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PRKDC anticorps

PRKDC Reactivité: Humain ELISA, IHC, ICC Hôte: Souris Monoclonal 3H6 unconjugated
N° du produit ABIN969366
  • Antigène Voir toutes PRKDC Anticorps
    PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))
    Reactivité
    • 165
    • 88
    • 47
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 154
    • 22
    • 3
    • 2
    Souris
    Clonalité
    • 151
    • 30
    Monoclonal
    Conjugué
    • 93
    • 11
    • 10
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Cet anticorp PRKDC est non-conjugé
    Application
    • 81
    • 67
    • 56
    • 32
    • 30
    • 28
    • 27
    • 24
    • 15
    • 12
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Fonction
    PRKDC Antibody
    Purification
    Ascitic fluid
    Immunogène
    Purified recombinant fragment of human PRKDC expressed in E. Coli.
    Clone
    3H6
    Isotype
    IgG1
  • Indications d'application

    ELISA: 1/10000

    ICC: 1/200 - 1/1000

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Durkin, Guo, Fryrear, Mihaylova, Gupta, Belgnaoui, Haoudi, Kupfer, Semmes: "HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase." dans: The Journal of biological chemistry, Vol. 283, Issue 52, pp. 36311-20, (2008) (PubMed).

    Huston, Lynch, Mohamed, Collins, Hill, MacLeod, Krause, Baillie, Houslay: "EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 35, pp. 12791-6, (2008) (PubMed).

  • Antigène
    PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))
    Autre désignation
    PRKDC (PRKDC Produits)
    Synonymes
    anticorps DNA-PKcs, anticorps DNAPK, anticorps DNPK1, anticorps HYRC, anticorps HYRC1, anticorps XRCC7, anticorps p350, anticorps DNA-PKCS, anticorps dna-pkcs, anticorps dnapk, anticorps dnpk1, anticorps hyrc, anticorps hyrc1, anticorps prkdc-A, anticorps xrcc7, anticorps PRKDC, anticorps AI326420, anticorps AU019811, anticorps DNAPDcs, anticorps DOXNPH, anticorps dxnph, anticorps p460, anticorps scid, anticorps slip, anticorps protein kinase, DNA-activated, catalytic polypeptide, anticorps protein kinase, DNA-activated, catalytic polypeptide L homeolog, anticorps DNA-dependent protein kinase catalytic subunit, anticorps protein kinase, DNA activated, catalytic polypeptide, anticorps PRKDC, anticorps prkdc.L, anticorps LOC100633457, anticorps Prkdc
    Sujet

    Description: The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity, PRKDC must be bound to DNA to express its catalytic properties.

    Aliases: HYRC, p350, DNAPK, DNPK1, HYRC1, XRCC7, DNA-PKcs, PRKDC

    Poids moléculaire
    46.9kDa
    ID gène
    5591
    HGNC
    5591
    UniProt
    P78527
    Pathways
    Réparation de l'ADN, Production of Molecular Mediator of Immune Response
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