PROZ anticorps
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- Antigène Voir toutes PROZ Anticorps
- PROZ (Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp PROZ est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Purification
- purified
- Immunogène
- Purified recombinant fragment of PROZ expressed in E. coli.
- Clone
- 2B4
- Isotype
- IgG1
- Top Product
- Discover our top product PROZ Anticorps primaire
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- Indications d'application
- ELISA: 1:10000, WB: 1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- 4°C, -20°C for long term storage
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Protein Z is reduced in chronic kidney disease and not elevated in patients on haemodialysis." dans: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Vol. 19, Issue 1, pp. 23-5, (2008) (PubMed).
: "Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications." dans: Journal of thrombosis and haemostasis : JTH, Vol. 3, Issue 3, pp. 497-501, (2005) (PubMed).
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Protein Z is reduced in chronic kidney disease and not elevated in patients on haemodialysis." dans: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Vol. 19, Issue 1, pp. 23-5, (2008) (PubMed).
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- Antigène
- PROZ (Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ))
- Autre désignation
- PROZ (PROZ Produits)
- Synonymes
- anticorps PZ, anticorps 1300015B06Rik, anticorps betaH1, anticorps protein Z, vitamin K dependent plasma glycoprotein, anticorps protein Z, vitamin K-dependent plasma glycoprotein, anticorps protein Z, vitamin K-dependent plasma glycoprotein b, anticorps hemoglobin Z, beta-like embryonic chain, anticorps PROZ, anticorps Proz, anticorps prozb, anticorps Hbb-bh1
- Sujet
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Description: PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency, there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.
Aliases: protein Z, PZ
- Poids moléculaire
- 45 kDa
- ID gène
- 8858
- HGNC
- 8858
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