Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

RSPO1 anticorps

RSPO1 Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 7A6 unconjugated
N° du produit ABIN969375
  • Antigène Voir toutes RSPO1 Anticorps
    RSPO1 (R-Spondin 1 (RSPO1))
    Reactivité
    • 43
    • 39
    • 34
    • 15
    • 15
    • 15
    • 15
    • 15
    Humain
    Hôte
    • 47
    • 5
    • 1
    Souris
    Clonalité
    • 48
    • 5
    Monoclonal
    Conjugué
    • 22
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp RSPO1 est non-conjugé
    Application
    • 36
    • 15
    • 13
    • 11
    • 11
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    purified
    Immunogène
    Purified recombinant fragment of R-spondin1 expressed in E. coli.
    Clone
    7A6
    Isotype
    IgG1
    Top Product
    Discover our top product RSPO1 Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Tomaselli, Megiorni, De Bernardo, Felici, Marrocco, Maggiulli, Grammatico, Remotti, Saccucci, Valentini, Mazzilli, Majore, Grammatico: "Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation." dans: Human mutation, Vol. 29, Issue 2, pp. 220-6, (2008) (PubMed).

    Parma, Radi, Vidal, Chaboissier, Dellambra, Valentini, Guerra, Schedl, Camerino: "R-spondin1 is essential in sex determination, skin differentiation and malignancy." dans: Nature genetics, Vol. 38, Issue 11, pp. 1304-9, (2006) (PubMed).

  • Antigène
    RSPO1 (R-Spondin 1 (RSPO1))
    Autre désignation
    R-spondin1 (RSPO1 Produits)
    Synonymes
    anticorps RGD1565558, anticorps CRISTIN3, anticorps RSPO, anticorps R-spondin, anticorps Rspondin, anticorps wu:fj81e05, anticorps zgc:92153, anticorps R-spondin 1, anticorps Rspo1, anticorps RSPO1, anticorps LOC100049655, anticorps rspo1
    Sujet

    Description: R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9 kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

    Aliases: RSPO1,CRISTIN3,FLJ40906

    Poids moléculaire
    28.9 kDa
    ID gène
    284654
    HGNC
    284654
Vous êtes ici:
Support technique