RSPO1 anticorps

N° du produit ABIN969375

Détail du produit anti-RSPO1 anticorps

Antigène: RSPO1 (R-Spondin 1 (RSPO1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RSPO1 est non-conjugé

Application: ELISA

Fonction: R-spondin1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of R-spondin1 expressed in E. Coli.

Clone: 7A6

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-RSPO1 (ABIN969375)

Tomaselli, Megiorni, De Bernardo, Felici, Marrocco, Maggiulli, Grammatico, Remotti, Saccucci, Valentini, Mazzilli, Majore, Grammatico: "Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation." dans: Human mutation, Vol. 29, Issue 2, pp. 220-6, (2008) (PubMed).

Parma, Radi, Vidal, Chaboissier, Dellambra, Valentini, Guerra, Schedl, Camerino: "R-spondin1 is essential in sex determination, skin differentiation and malignancy." dans: Nature genetics, Vol. 38, Issue 11, pp. 1304-9, (2006) (PubMed).

Détails sur RSPO1

Antigène: RSPO1 (R-Spondin 1 (RSPO1))

Autre désignation: R-spondin1 (RSPO1 Produits)

Synonymes: anticorps RGD1565558, anticorps CRISTIN3, anticorps RSPO, anticorps R-spondin, anticorps Rspondin, anticorps wu:fj81e05, anticorps zgc:92153, anticorps R-spondin 1, anticorps Rspo1, anticorps RSPO1, anticorps LOC100049655, anticorps rspo1

Sujet:

Description: R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9 kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

Aliases: RSPO1,CRISTIN3,FLJ40906

Poids moléculaire: 28.9kDa

ID gène: 284654

HGNC: 284654

UniProt: Q2MKA7