RSPO1 anticorps
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- Antigène Voir toutes RSPO1 Anticorps
- RSPO1 (R-Spondin 1 (RSPO1))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp RSPO1 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Purification
- purified
- Immunogène
- Purified recombinant fragment of R-spondin1 expressed in E. coli.
- Clone
- 7A6
- Isotype
- IgG1
- Top Product
- Discover our top product RSPO1 Anticorps primaire
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- Indications d'application
- ELISA: 1:10000, WB: 1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- 4°C, -20°C for long term storage
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Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation." dans: Human mutation, Vol. 29, Issue 2, pp. 220-6, (2008) (PubMed).
: "R-spondin1 is essential in sex determination, skin differentiation and malignancy." dans: Nature genetics, Vol. 38, Issue 11, pp. 1304-9, (2006) (PubMed).
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Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation." dans: Human mutation, Vol. 29, Issue 2, pp. 220-6, (2008) (PubMed).
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- Antigène
- RSPO1 (R-Spondin 1 (RSPO1))
- Autre désignation
- R-spondin1 (RSPO1 Produits)
- Synonymes
- anticorps RGD1565558, anticorps CRISTIN3, anticorps RSPO, anticorps R-spondin, anticorps Rspondin, anticorps wu:fj81e05, anticorps zgc:92153, anticorps R-spondin 1, anticorps Rspo1, anticorps RSPO1, anticorps LOC100049655, anticorps rspo1
- Sujet
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Description: R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9 kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
Aliases: RSPO1,CRISTIN3,FLJ40906
- Poids moléculaire
- 28.9 kDa
- ID gène
- 284654
- HGNC
- 284654
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