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RAG2 anticorps (AA 350-527)

RAG2 Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 4D5 unconjugated
N° du produit ABIN969379
  • Antigène Voir toutes RAG2 Anticorps
    RAG2 (Recombination Activating Gene 2 (RAG2))
    Épitope
    • 15
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 350-527
    Reactivité
    • 45
    • 14
    • 13
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 40
    • 6
    Souris
    Clonalité
    • 42
    • 4
    Monoclonal
    Conjugué
    • 22
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RAG2 est non-conjugé
    Application
    • 20
    • 13
    • 13
    • 11
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    purified
    Immunogène
    Purified recombinant fragment of human RAG2(350-527aa) expressed in E. coli.
    Clone
    4D5
    Isotype
    IgG1
    Top Product
    Discover our top product RAG2 Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Nagawa, Hirose, Nishizumi, Nishihara, Sakano: "Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA." dans: The Journal of biological chemistry, Vol. 279, Issue 37, pp. 38360-8, (2004) (PubMed).

  • Antigène
    RAG2 (Recombination Activating Gene 2 (RAG2))
    Autre désignation
    RAG2 (RAG2 Produits)
    Synonymes
    anticorps RAG-2, anticorps Rag-2, anticorps rag-2, anticorps zgc:136743, anticorps recombination activating 2, anticorps recombination activating gene 2, anticorps recombination activating gene 2 S homeolog, anticorps RAG2, anticorps Rag2, anticorps rag2, anticorps rag2.S
    Sujet

    Description: This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

    Aliases: RAG-2, RAG2

    Poids moléculaire
    59 kDa
    ID gène
    5897
    HGNC
    5897
    Pathways
    Chromatin Binding, Production of Molecular Mediator of Immune Response
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