TRKA anticorps (AA 33-423)
-
- Antigène Voir toutes TRKA (NTRK1) Anticorps
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
-
Épitope
- AA 33-423
-
Reactivité
- Humain
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp TRKA est non-conjugé
-
Application
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
- Purification
- purified
- Immunogène
- Purified recombinant extracellular fragment of human TrkA (aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
- Clone
- 6B2
- Isotype
- IgG1
- Top Product
- Discover our top product NTRK1 Anticorps primaire
-
-
- Indications d'application
- ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- 4°C, -20°C for long term storage
-
-
TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent." dans: Traffic (Copenhagen, Denmark), Vol. 9, Issue 7, pp. 1146-56, (2008) (PubMed).
: "Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells." dans: DNA repair, Vol. 7, Issue 10, pp. 1757-64, (2008) (PubMed).
: "
-
TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent." dans: Traffic (Copenhagen, Denmark), Vol. 9, Issue 7, pp. 1146-56, (2008) (PubMed).
-
- Antigène
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
- Autre désignation
- TrkA (NTRK1 Produits)
- Synonymes
- anticorps MTC, anticorps TRK, anticorps TRK1, anticorps TRKA, anticorps Trk-A, anticorps p140-TrkA, anticorps CDHF12, anticorps CDHR16, anticorps HSCR1, anticorps MEN2A, anticorps MEN2B, anticorps MTC1, anticorps PTC, anticorps RET-ELE1, anticorps RET51, anticorps Trk, anticorps C80751, anticorps Tkr, anticorps TrkA, anticorps trk, anticorps trka, anticorps CTRKA, anticorps trkA, anticorps neurotrophic receptor tyrosine kinase 1, anticorps ret proto-oncogene, anticorps neurotrophic tyrosine kinase, receptor, type 1, anticorps NTRK1, anticorps RET, anticorps Ntrk1, anticorps ntrk1
- Sujet
-
Description: TrkA, also known as NTRK1, MTC, TRK, TRK1. It is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Aliases: NTRK1, MTC, TRK, TRK1
- Poids moléculaire
- 87.4 kDa
- ID gène
- 4914
- HGNC
- 4914
- Pathways
- Signalisation RTK, Neurotrophin Signaling Pathway, cAMP Metabolic Process
-