ZAP70 anticorps

N° du produit ABIN969464

Détail du produit anti-ZAP70 anticorps

Antigène: ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ZAP70 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Fonction: ZAP70 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human ZAP70 expressed in E. Coli.

Clone: 3D2A4

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-ZAP70 (ABIN969464)

Gelkop, Gish, Babichev, Pawson, Isakov: "T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 12, pp. 8123-32, (2005) (PubMed).

Carreras, Villamor, Colomo, Moreno, Ramón y Cajal, Crespo, Tort, Bosch, López-Guillermo, Colomer, Montserrat, Campo: "Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms." dans: The Journal of pathology, Vol. 205, Issue 4, pp. 507-13, (2005) (PubMed).

Hivroz: "[Everything you ever wanted to know about ZAP-70]." dans: Médecine sciences : M/S, Vol. 21, Issue 2, pp. 150-5, (2005) (PubMed).

Détails sur ZAP70

Antigène: ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))

Autre désignation: ZAP70 (ZAP70 Produits)

Synonymes: anticorps SRK, anticorps STCD, anticorps STD, anticorps TZK, anticorps ZAP-70, anticorps 70kDa, anticorps AI327364, anticorps Srk, anticorps mrtle, anticorps mur, anticorps zap70, anticorps MGC80670, anticorps MGC88962, anticorps ZAP70, anticorps zgc:110383, anticorps zeta chain of T-cell receptor associated protein kinase 70, anticorps putative tyrosine-protein kinase zap-70, anticorps zeta-chain (TCR) associated protein kinase, anticorps zeta chain of T cell receptor associated protein kinase 70, anticorps zeta-chain (TCR) associated protein kinase 70kDa, anticorps zeta chain of T cell receptor associated protein kinase 70kDa L homeolog, anticorps zeta chain of T cell receptor associated protein kinase 70kDa, anticorps tyrosine-protein kinase ZAP-70, anticorps ZAP70, anticorps Smp_149470, anticorps Zap70, anticorps zap70.L, anticorps zap70, anticorps LOC707555, anticorps LOC100342021, anticorps LOC100390922, anticorps LOC100542877

Sujet:

Description: ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. ZAP70 controls TCR(T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.

Aliases: SRK, STD, TZK

Poids moléculaire: 70kDa

ID gène: 7535

HGNC: 7535

UniProt: P43403

Pathways: TCR Signaling, Ubiquitin Proteasome Pathway