MCL-1 anticorps

N° du produit ABIN969485

Détail du produit anti-MCL-1 anticorps

Antigène: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MCL-1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Fonction: MCL-1 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human MCL-1 expressed in E. Coli.

Clone: 8C6D4B1

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-MCL-1 (ABIN969485)

Richert, Schwertfeger, Ryder, Anderson: "An atlas of mouse mammary gland development." dans: Journal of mammary gland biology and neoplasia, Vol. 5, Issue 2, pp. 227-41, (2001) (PubMed).

MacLachlan, Hébert: "Statement concerning euthanasia and physician-assisted suicide. Ethics Committee of the College of Family Physicians of Canada." dans: Canadian family physician Médecin de famille canadien, Vol. 46, pp. 254-6, 264-7, (2000) (PubMed).

Détails sur MCL-1

Antigène: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Autre désignation: MCL-1 (MCL1 Produits)

Synonymes: anticorps BCL2L3, anticorps EAT, anticorps MCL1-ES, anticorps MCL1L, anticorps MCL1S, anticorps Mcl-1, anticorps TM, anticorps bcl2-L-3, anticorps mcl1/EAT, anticorps AW556805, anticorps mcl-1, anticorps fb72f02, anticorps wu:fb70a08, anticorps wu:fb72f02, anticorps zfMLP1, anticorps zfMcl-1a, anticorps zgc:109835, anticorps zgc:109763, anticorps E3, anticorps E3-2, anticorps RNE3, anticorps RNU107, anticorps SNORA63A, anticorps elF-4AII, anticorps MCL1, BCL2 family apoptosis regulator, anticorps myeloid cell leukemia sequence 1, anticorps MCL1, BCL2 family apoptosis regulator a, anticorps MCL1, BCL2 family apoptosis regulator b, anticorps small nucleolar RNA, H/ACA box 63, anticorps MCL1, anticorps Mcl1, anticorps mcl1a, anticorps mcl1b, anticorps SNORA63

Sujet:

Description: Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that
increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or
exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related
protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This
monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.

Aliases: EAT, MCL1L, MCL1S

Poids moléculaire: 37kDa

ID gène: 4170

HGNC: 4170

UniProt: Q07820

Pathways: Signalisation MAPK