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MTDH anticorps

MTDH Reactivité: Humain WB, IHC, ELISA, FACS Hôte: Souris Monoclonal 2F11C3 unconjugated
N° du produit ABIN969496
  • Antigène Voir toutes MTDH Anticorps
    MTDH (Metadherin (MTDH))
    Reactivité
    • 49
    • 18
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 41
    • 6
    • 3
    Souris
    Clonalité
    • 46
    • 4
    Monoclonal
    Conjugué
    • 28
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MTDH est non-conjugé
    Application
    • 40
    • 14
    • 13
    • 13
    • 10
    • 9
    • 9
    • 8
    • 7
    • 4
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)
    Purification
    purified
    Immunogène
    Purified recombinant fragment of human Metadherin expressed in E. coli.
    Clone
    2F11C3
    Isotype
    IgG1
    Top Product
    Discover our top product MTDH Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Antibody are purified by protein G affinity chromatography. Liquid in PBS containing 50 % glycerol and 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Britt, Yang, Yang, Flanagan, Callanan, Lim, Lin, Hixson: "Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells." dans: Experimental cell research, Vol. 300, Issue 1, pp. 134-48, (2004) (PubMed).

    Brown, Ruoslahti: "Metadherin, a cell surface protein in breast tumors that mediates lung metastasis." dans: Cancer cell, Vol. 5, Issue 4, pp. 365-74, (2004) (PubMed).

  • Antigène
    MTDH (Metadherin (MTDH))
    Autre désignation
    Metadherin (MTDH Produits)
    Synonymes
    anticorps MGC75963, anticorps 2610103J23Rik, anticorps 3D3, anticorps 3D3/Lyric, anticorps AEG-1, anticorps AV353288, anticorps D8Bwg1112e, anticorps Lyric, anticorps AEG1, anticorps LYRIC, anticorps LYRIC/3D3, anticorps metadherin, anticorps mtdh, anticorps MTDH, anticorps Mtdh
    Sujet

    Description: Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain, blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

    Aliases: 3D3, AEG1, LYRIC, MTDH

    Poids moléculaire
    64 kDa
    ID gène
    92140
    HGNC
    92140
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization
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