Doublecortin anticorps (AA 362-411)

N° du produit ABIN969513

Détail du produit anti-Doublecortin anticorps

Antigène: Doublecortin (DCX)

Épitope: AA 362-411

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Doublecortin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Fonction: DCX Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human DCX (AA: 362-411) expressed in E. Coli.

Clone: 2G5

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Doublecortin (ABIN969513)

Evangelisti, Florian, Massimi, Dominici, Giannini, Galardi, Buè, Massalini, McDowell, Messi, Gulino, Farace, Ciafrè: "MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 12, pp. 4276-87, (2009) (PubMed).

Détails sur Doublecortin

Antigène: Doublecortin (DCX)

Autre désignation: DCX (DCX Produits)

Synonymes: anticorps DCX, anticorps DBCN, anticorps DC, anticorps LISX, anticorps SCLH, anticorps XLIS, anticorps Dbct, anticorps 18C15.5, anticorps doublecortin, anticorps DCX, anticorps Dcx

Sujet:

Description: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Aliases: DC, DBCN, LISX, SCLH, XLIS

Poids moléculaire: 49.3kDa

ID gène: 1641

HGNC: 1641

UniProt: O43602