E2F1 anticorps (AA 69-223)

N° du produit ABIN969516

Détail du produit anti-E2F1 anticorps

Antigène: E2F1 (E2F Transcription Factor 1 (E2F1))

Épitope: AA 69-223

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp E2F1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Fonction: E2F1 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human E2F1 (AA: 69-223) expressed in E. Coli.

Clone: 8G9

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-E2F1 (ABIN969516)

Zhou, Jiang, Xia, Zhang: "Comparison of the therapeutic effects of lobaplatin and carboplatin on retinoblastoma in vitro and in vivo." dans: International journal of oncology, Vol. 57, Issue 3, pp. 697-706, (2020) (PubMed).

Okazaki, Matsunaga, Okazaki, Utoguchi, Suzuki, Maruyama, Koyanagi, Ohdo: "Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice." dans: Cancer research, Vol. 70, Issue 15, pp. 6238-46, (2010) (PubMed).

Gurtner, Fuschi, Martelli, Manni, Artuso, Simonte, Ambrosino, Antonini, Folgiero, Falcioni, Sacchi, Piaggio: "Transcription factor NF-Y induces apoptosis in cells expressing wild-type p53 through E2F1 upregulation and p53 activation." dans: Cancer research, Vol. 70, Issue 23, pp. 9711-20, (2010) (PubMed).

Locatelli, Bosotti, Ciomei, Brasca, Calogero, Mercurio, Fiorentini, Bertolotti, Scacheri, Scaburri, Galvani, Pesenti, De Baere, Soria, Lazar, Isacchi: "Transcriptional analysis of an E2F gene signature as a biomarker of activity of the cyclin-dependent kinase inhibitor PHA-793887 in tumor and skin biopsies from a phase I clinical study." dans: Molecular cancer therapeutics, Vol. 9, Issue 5, pp. 1265-73, (2010) (PubMed).

Détails sur E2F1

Antigène: E2F1 (E2F Transcription Factor 1 (E2F1))

Autre désignation: E2F1 (E2F1 Produits)

Synonymes: anticorps CG6376, anticorps DRTF1/E2F, anticorps DmE2F-1, anticorps Dmel\\CG6376, anticorps Dp, anticorps E(Sev-CycE)3A, anticorps E(var)3-93E, anticorps E(var)3-95E, anticorps E(var)93E, anticorps E2F, anticorps E2F-1, anticorps E2F1, anticorps E2f1, anticorps Evar(3)164, anticorps dE2F, anticorps dE2F1, anticorps dE2f, anticorps dE2f1, anticorps de2f1, anticorps def21, anticorps drosE2F1, anticorps e2f, anticorps e2f1, anticorps l(3)07172, anticorps l(3)j3B1, anticorps l(3)j3C2, anticorps l(3)rM729, anticorps RBAP1, anticorps RBBP3, anticorps RBP3, anticorps mKIAA4009, anticorps xE2F, anticorps ATE2FB, anticorps E2F TRANSCRIPTION FACTOR-1 E2F1, anticorps E2F transcription factor 1, anticorps E2FB, anticorps E2FB TRANSCRIPTION FACTOR, anticorps E2F transcription factor 1, anticorps E2F transcription factor 1 L homeolog, anticorps E2f1, anticorps E2F1, anticorps e2f1.L

Sujet:

Description: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Aliases: RBP3, E2F-1, RBAP1, RBBP3

Poids moléculaire: 46.9kDa

ID gène: 1869

HGNC: 1869

UniProt: Q01094

Pathways: Signalisation p53, Cycle Cellulaire, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagy