INCENP anticorps (AA 369-583)
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- Antigène Voir toutes INCENP Anticorps
- INCENP (Inner Centromere Protein Antigens 135/155kDa (INCENP))
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Épitope
- AA 369-583
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp INCENP est non-conjugé
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Application
- Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (IHC)
- Fonction
- INCENP Antibody
- Purification
- Purified antibody
- Immunogène
- Purified recombinant fragment of human INCENP (AA: 369-583) expressed in E. Coli.
- Clone
- 3D2
- Isotype
- IgG1
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- Indications d'application
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis." dans: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 16, Issue 6, pp. 652-69, (2011) (PubMed).
: "INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization." dans: The Journal of cell biology, Vol. 187, Issue 5, pp. 637-53, (2009) (PubMed).
: "
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Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis." dans: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 16, Issue 6, pp. 652-69, (2011) (PubMed).
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- Antigène
- INCENP (Inner Centromere Protein Antigens 135/155kDa (INCENP))
- Autre désignation
- INCENP (INCENP Produits)
- Synonymes
- anticorps INCENP, anticorps LOC572121, anticorps 2700067E22Rik, anticorps AU019509, anticorps C130081E20, anticorps C77457, anticorps XL-INCENP, anticorps incenp, anticorps incenp-a, anticorps incenp-b, anticorps xINC, anticorps xIncenp, anticorps xl-incenp, anticorps inner centromere protein, anticorps inner centromere protein S homeolog, anticorps inner centromere protein L homeolog, anticorps INCENP, anticorps Incenp, anticorps incenp.S, anticorps incenp, anticorps incenp.L
- Sujet
- In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A, MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143), MCAK (MIM 604538), KID (MIM 603213), cytoplasmic dynein (e.g., MIM 600112), CliPs (e.g., MIM 179838), and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis
- Poids moléculaire
- 105.4kDa
- ID gène
- 3619
- HGNC
- 3619
- UniProt
- Q9NQS7
- Pathways
- Cycle Cellulaire
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