INCENP anticorps (AA 369-583)

N° du produit ABIN969529

Détail du produit anti-INCENP anticorps

Antigène: INCENP (Inner Centromere Protein Antigens 135/155kDa (INCENP))

Épitope: AA 369-583

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp INCENP est non-conjugé

Application: Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (IHC)

Fonction: INCENP Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human INCENP (AA: 369-583) expressed in E. Coli.

Clone: 3D2

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-INCENP (ABIN969529)

Ban, Nishida, Urano: "Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis." dans: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 16, Issue 6, pp. 652-69, (2011) (PubMed).

Xu, Ogawa, Vagnarelli, Bergmann, Hudson, Ruchaud, Fukagawa, Earnshaw, Samejima: "INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization." dans: The Journal of cell biology, Vol. 187, Issue 5, pp. 637-53, (2009) (PubMed).

Détails sur INCENP

Antigène: INCENP (Inner Centromere Protein Antigens 135/155kDa (INCENP))

Autre désignation: INCENP (INCENP Produits)

Sujet: In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A, MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143), MCAK (MIM 604538), KID (MIM 603213), cytoplasmic dynein (e.g., MIM 600112), CliPs (e.g., MIM 179838), and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis

Poids moléculaire: 105.4kDa

ID gène: 3619

HGNC: 3619

UniProt: Q9NQS7

Pathways: Cycle Cellulaire