Lp(a) anticorps (AA 1823-2013)

N° du produit ABIN969533

Détail du produit anti-Lp(a) anticorps

Antigène: Lp(a) (Lipoprotein (Lp(a)))

Épitope: AA 1823-2013

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Lp(a) est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Fonction: LPA Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human LPA (AA: 1823-2013) expressed in E. Coli.

Clone: 4H1

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Lp(a) (ABIN969533)

Nicholls, Tang, Scoffone, Brennan, Hartiala, Allayee, Hazen: "Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy." dans: Journal of lipid research, Vol. 51, Issue 10, pp. 3055-61, (2010) (PubMed).

Rodger, Le Gal, Carrier, Betancourt, Kahn, Wells, Anderson, Lacut, Chagnon, Solymoss, Crowther, Perrier, White, Vickars, Ramsay, Kovacs: "Serum lipoprotein (a) levels in patients with first unprovoked venous thromboembolism is not associated with subsequent risk of recurrent VTE." dans: Thrombosis research, Vol. 126, Issue 3, pp. 222-6, (2010) (PubMed).

Détails sur Lp(a)

Antigène: Lp(a) (Lipoprotein (Lp(a)))

Autre désignation: LPA

Sujet:

Description: The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence.

Aliases: LP, AK38, APOA

Poids moléculaire: 501kDa

ID gène: 4018

HGNC: 4018

UniProt: P08519