PAX5 anticorps (AA 235-382)
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- Antigène Voir toutes PAX5 Anticorps
- PAX5 (Paired Box 5 (PAX5))
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Épitope
- AA 235-382
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp PAX5 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Purification
- purified
- Immunogène
- Purified recombinant fragment of human PAX5 (AA: 235-382) expressed in E. coli.
- Clone
- 7D3
- Isotype
- IgG1
- Top Product
- Discover our top product PAX5 Anticorps primaire
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- Indications d'application
- ELISA: 1:10000, WB: 1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- 4°C, -20°C for long term storage
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Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study. ..." dans: Blood, Vol. 115, Issue 15, pp. 3089-97, (2010) (PubMed).
: "Multiple isoforms of PAX5 are expressed in both lymphomas and normal B-cells." dans: British journal of haematology, Vol. 147, Issue 3, pp. 328-38, (2009) (PubMed).
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Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study. ..." dans: Blood, Vol. 115, Issue 15, pp. 3089-97, (2010) (PubMed).
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- Antigène
- PAX5 (Paired Box 5 (PAX5))
- Autre désignation
- PAX5 (PAX5 Produits)
- Synonymes
- anticorps PAX5, anticorps BSAP, anticorps Pax-5, anticorps pax5-a, anticorps RGD1565236, anticorps EBB-1, anticorps KLP, anticorps Pax[Zf-b], anticorps noi, anticorps pax2.1, anticorps pax2a, anticorps paxzf-b, anticorps paired box 5, anticorps paired box 5 L homeolog, anticorps PAX5, anticorps pax5.L, anticorps Pax5, anticorps pax5
- Sujet
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Description: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9,14)(p13,q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
Aliases: BSAP
- Poids moléculaire
- 45 kDa
- ID gène
- 5079
- HGNC
- 5079
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