PPM1A anticorps (AA 202-382)
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- Antigène Voir toutes PPM1A Anticorps
- PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
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Épitope
- AA 202-382
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Reactivité
- Humain, Singe
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp PPM1A est non-conjugé
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Application
- Western Blotting (WB), ELISA, Flow Cytometry (FACS)
- Purification
- purified
- Immunogène
- Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. coli. ,
- Clone
- 7F12
- Isotype
- IgG1
- Top Product
- Discover our top product PPM1A Anticorps primaire
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- Indications d'application
- ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- 4°C, -20°C for long term storage
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Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants." dans: Biological psychiatry, Vol. 69, Issue 4, pp. 360-5, (2011) (PubMed).
: "PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation." dans: Cellular signalling, Vol. 21, Issue 1, pp. 95-102, (2008) (PubMed).
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Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants." dans: Biological psychiatry, Vol. 69, Issue 4, pp. 360-5, (2011) (PubMed).
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- Antigène
- PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
- Autre désignation
- PPM1A (PPM1A Produits)
- Synonymes
- anticorps PP2C-ALPHA, anticorps PP2CA, anticorps PP2Calpha, anticorps pp2ca1, anticorps ppp1r13b, anticorps si:ch211-253p18.1, anticorps wu:fd42g12, anticorps zgc:153820, anticorps 2310003C21Rik, anticorps 2900017D14Rik, anticorps AI427932, anticorps AU017636, anticorps MMPa-2, anticorps MPPa-1, anticorps Pp2c1, anticorps pp2c-alpha, anticorps pp2ca, anticorps pp2calpha, anticorps pp2ca2, anticorps protein phosphatase, Mg2+/Mn2+ dependent 1A, anticorps protein phosphatase, Mg2+/Mn2+ dependent, 1Ab, anticorps protein phosphatase 1A, magnesium dependent, alpha isoform, anticorps protein phosphatase, Mg2+/Mn2+ dependent, 1A, anticorps protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog, anticorps protein phosphatase, Mg2+/Mn2+ dependent, 1Aa, anticorps PPM1A, anticorps ppm1ab, anticorps Ppm1a, anticorps ppm1a.L, anticorps ppm1aa
- Sujet
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Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Aliases: PP2CA, PP2Calpha, PP2C-ALPHA
- Poids moléculaire
- 42.4 kDa
- ID gène
- 5494
- HGNC
- 5494
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