GLUD1 anticorps

N° du produit ABIN99811

Détail du produit anti-GLUD1 anticorps

Antigène: GLUD1 (Glutamate Dehydrogenase 1 (GLUD1))

Reactivité: Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLUD1 est non-conjugé

Application: Western Blotting (WB), ELISA

Attributs du produit: Concentration Definition: by Refractometry

Immunogène: This antibody was prepared from whole rabbit serum produced by repeated immunizations with a full length Glutamate Dehydrogenase protein isolated from Bovine Liver.
Immunogentype:Native

Information d'application

Indications d'application: This antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Bovine glutamate dehydrogenase exists as a homohexamer located within the mitochondrial matrix.  Expect a band approximately 56 kDa in size corresponding to glutamate dehydrogenase monomer subunit by western blotting in the appropriate cell or tissue extract.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Restore with deionized water (or equivalent)

Concentration: 85 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-GLUD1 (ABIN99811)

Pougovkina, te Brinke, Ofman, van Cruchten, Kulik, Wanders, Houten, de Boer: "Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation." dans: Human molecular genetics, Vol. 23, Issue 13, pp. 3513-22, (2015) (PubMed).

Frigerio, Karaca, De Roo, Mlynárik, Skytt, Carobbio, Pajęcka, Waagepetersen, Gruetter, Muller, Maechler: "Deletion of Glud1 (Glutamate Dehydrogenase 1) in the Central Nervous System affects glutamate handling without altering synaptic transmission." dans: Journal of neurochemistry, (2012) (PubMed).

Anthonio, Brees, Baumgart-Vogt, Hongu, Huybrechts, Van Dijck, Mannaerts, Kanaho, Van Veldhoven, Fransen: "Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6." dans: BMC cell biology, Vol. 10, pp. 58, (2009) (PubMed).

Huybrechts, Van Veldhoven, Hoffman, Zeevaert, de Vos, Demaerel, Brams, Jaeken, Fransen, Cassiman: "Identification of a novel PEX14 mutation in Zellweger syndrome." dans: Journal of medical genetics, Vol. 45, Issue 6, pp. 376-83, (2008) (PubMed).

Korolainen, Goldsteins, Nyman, Alafuzoff, Koistinaho, Pirttilae: "Oxidative modification of proteins in the frontal cortex of Alzheimer's disease brain." dans: Neurobiology of aging, Vol. 27, Issue 1, pp. 42-53, (2005) (PubMed).

Carobbio, Ishihara, Fernandez-Pascual, Bartley, Martin-Del-Rio, Maechler: "Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets." dans: Diabetologia, Vol. 47, Issue 2, pp. 266-76, (2004) (PubMed).

Fransen, Vastiau, Brees, Brys, Mannaerts, Van Veldhoven: "Potential role for Pex19p in assembly of PTS-receptor docking complexes." dans: The Journal of biological chemistry, Vol. 279, Issue 13, pp. 12615-24, (2004) (PubMed).

Akutsu, Miyazaki: "Biochemical and immunohistochemical studies on tropomyosin and glutamate dehydrogenase in the chicken liver." dans: Zoological science, Vol. 19, Issue 3, pp. 275-86, (2002) (PubMed).

Détails sur GLUD1

Antigène: GLUD1 (Glutamate Dehydrogenase 1 (GLUD1))

Autre désignation: Glutamate Dehydrogenase (GLUD1 Produits)

Synonymes: anticorps GDH, anticorps gdh1, anticorps GDH 1, anticorps glud1, anticorps GLUD1, anticorps cb719, anticorps wu:fb16e02, anticorps wu:fb58f12, anticorps wu:fe37f03, anticorps wu:fj43f02, anticorps zgc:192851, anticorps zgc:55630, anticorps GDH1, anticorps GLUD, anticorps AI118167, anticorps Gdh-X, anticorps Glud, anticorps Gludl, anticorps Ac2-281, anticorps Gdh1, anticorps Gludeha, anticorps MRG-2, anticorps GLUTAMATE DECARBOXYLASE 1, anticorps GLUTAMATE DEHYDROGENASE 1, anticorps MRG7.13, anticorps MRG7_13, anticorps glutamate dehydrogenase 1, anticorps C2H1orf130, anticorps legdh1, anticorps cb622, anticorps wu:fc33g09, anticorps wu:fc66a10, anticorps zgc:77186, anticorps glutamate dehydrogenase 1, anticorps glutamate dehydrogenase 1 S homeolog, anticorps glutamate dehydrogenase 1, mitochondrial, anticorps glutamate dehydrogenase 1b, anticorps glutamate dehydrogenase, anticorps non-compact myelin associated protein, anticorps glutamate dehydrogenase 1a, anticorps GLUD1, anticorps GDH1, anticorps glud1, anticorps glud1.S, anticorps LOC693461, anticorps glud1b, anticorps Glud1, anticorps HACJB3_RS00320, anticorps LOC100587725, anticorps NCMAP, anticorps gdh1, anticorps glud1a

Sujet: Glutamate is a major excitatory neurotransmitter. One enzyme central to the metabolism of glutamate is glutamate dehydrogenase (GDH1; EC 1.4.1.3), that catalyzes the reversible deamination of L-glutamate to 2-oxoglutarate using NAD+ or NADP+. Mammalian GDH is composed of six identical subunits, and the regulation of GDH is very complex.  It has been a major goal to identify the substrate and regulatory binding sites of GDH. It is only in recent years that the three-dimensional structure of GDH from microorganisms is available. Very recently, crystallization of bovine liver GDH was reported for the first time from the mammalian sources. However, remarkably little is known about the detailed structure of mammalian GDH, especially the brain enzymes.
Synonyms: Glutamate dehydrogenase 1, mitochondrial GDH 1 EC=1.4.1.3

ID gène: 281785, 32880221

UniProt: P00366

Pathways: Positive Regulation of Peptide Hormone Secretion, L'effet Warburg