Glycogen Synthase 1 anticorps (pSer640)

N° du produit ABIN99926

Détail du produit anti-Glycogen Synthase 1 anticorps

Antigène: Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

Épitope: pSer640

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glycogen Synthase 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: Human Muscle Glycogen Synthase phospho peptide corresponding to a region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).

Isotype: IgG

Information d'application

Indications d'application: This phospho specific polyclonal antibody was tested by immunoblotting and ELISA.  By ELISA the antibody was found to be reactive with the phosphorylated form of the immunizing peptide and minimally reactive with the non-phosphorylated form of the immunizing peptide.   Immunoblotting will detect human and mouse muscle glycogen synthase.  Although not tested, this antibody is likely functional in immunohistochemistry and immunoprecipitation.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur Glycogen Synthase 1

Antigène: Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

Autre désignation: Glycogen Synthase 1 (GYS1 Produits)

Synonymes: anticorps GSY, anticorps GYS, anticorps GYS1, anticorps zgc:63701, anticorps GYS2, anticorps Gys3, anticorps MGS, anticorps glycogen synthase 1, anticorps glycogen synthase 1 (muscle), anticorps glycogen synthase 1, muscle, anticorps GYS1, anticorps gys1, anticorps Gys1

Sujet: Anti-Glycogen synthase 1 pS640 is validated by IHC, Western Blot and ELISA. Human muscle glycogen synthase (GS) is responsible for the biosynthesis of glycogen from phosphorylated glucose units.  Mammalian liver and muscle contain GS consisting of four subunits with a total molecular weight of 360,000.  GS is subject to regulation through both allosteric and covalent modification and occurs in two forms:  the phosphorylated inactive form, and the dephos-phorylated active form.  GS is inactivated by the serine/threonine kinase called glycogen synthase kinase-3b that mainly functions to phos-phorylate muscle glycogen synthase.  This antibody is specific for the phosphorylated form of GS at S640.   Phosphorylation of GS at S640 has been associated with Antiphospholipid Antibody Syndrome.
Synonyms: Glycogen antibody, Glycogen synthase 1 (muscle) antibody, Glycogen synthase 1 antibody, Glycogen synthase1 antibody, GSY antibody, GYS 1 antibody, GYS antibody, GYS1 antibody, Starchsynthase muscle antibody

ID gène: 2997

UniProt: P13807

Pathways: Signalisation PI3K-Akt, AMPK Signaling, Cellular Glucan Metabolic Process