APAF1 Produits
(Apoptotic Peptidase Activating Factor 1 (APAF1))
Catégories
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Catégories APAF1 en vedette
APAF1 Anticorps
High quality antibodies with extensive validation data.
APAF1 Kits ELISA
Reliable ELISA kits for a wide range of species.
APAF1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
APAF1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (7)
N° du produit
ABIN1678685
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
- (5)
N° du produit
ABIN7433081
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, ICC, FACS, Neut
Validations
- (5)
N° du produit
ABIN5611196
Quantité
100 μL
Fiche technique
Fiche technique
APAF1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6964972
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6964971
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6953881
Quantité
96 tests
Fiche technique
Fiche technique
APAF1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1345275
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7411675
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7393076
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits APAF1
: "Optimization of Experimental Variables Influencing Apoptosome Biosensor in HEK293T Cells." dans: Sensors (Basel, Switzerland), Vol. 20, Issue 6, (2020) (PubMed).: "A new split-luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation." dans: FEBS open bio, Vol. 9, Issue 7, pp. 1194-1203, (2020) (PubMed).
: "Apoptosome formation upon overexpression of native and truncated Apaf-1 in cell-free and cell-based systems." dans: Archives of biochemistry and biophysics, Vol. 642, pp. 46-51, (2019) (PubMed).
: "LY333531, a PKCβ inhibitor, attenuates glomerular endothelial cell apoptosis in the early stage of mouse diabetic nephropathy via down-regulating swiprosin-1." dans: Acta pharmacologica Sinica, Vol. 38, Issue 7, pp. 1009-1023, (2018) (PubMed).
: "Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma." dans: Nature medicine, Vol. 21, Issue 9, pp. 1060-4, (2015) (PubMed).
: "Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer." dans: Virchows Archiv : an international journal of pathology, Vol. 467, Issue 5, pp. 563-70, (2015) (PubMed).
: "Human interleukin 23 receptor induces cell apoptosis in mammalian cells by intrinsic mitochondrial pathway associated with the down-regulation of RAS/mitogen-activated protein kinase and signal ..." dans: International journal of molecular sciences, Vol. 14, Issue 12, pp. 24656-69, (2014) (PubMed).
: "[Intralobar sequestration in elderly patient, report of a case]" dans: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 61, Issue 9, pp. 812-5, (2008) (PubMed).
: "Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1." dans: Molecular cell, Vol. 25, Issue 2, pp. 181-92, (2007) (PubMed).
: "Mechanical aspects of apoptosome assembly." dans: Current opinion in cell biology, Vol. 18, Issue 6, pp. 677-84, (2006) (PubMed).
Synonymes et noms alternatifs relatifs à APAF1
Death-associated APAF1-related killer (Dark), apoptotic peptidase activating factor 1 L homeolog (apaf1.L), apoptotic peptidase activating factor 1 (apaf1), apoptotic peptidase activating factor 1 (APAF1), apoptotic peptidase activating factor 1 (Apaf1), 6230400I06Rik, anon-53Fa, Apaf-1, apaf-1, APAF-1, APAF1, Apaf1, apaf1, Apaf1l, arc, ARK, ark, CED4, CG6829, D-Apaf-1, dapaf, Dapaf-1, dAPAF-1, dApaf-1, dapaf-1, dApaf-1/DARK/HAC-1, Dapaf-1/HAC-1, dapaf-1L, dapaf-1S, dApaf1, DARK, Dark, dArk, dark, Dark/Apaf-I, dark/dapaf-1/hac-1, Dark/Dapaf-1/HAC1, Dark/Hac-1/dApaf-1, dark/hac-1/dapaf-1, Dark/Hac-1/dApaf1, Dmel\\CG6829, fog, Hac-1, hac-1, Hac-1/Dark, Hac1, hac1, l(2)SH0173, mKIAA0413, T1, zgc:136543Protein level used designations for APAF1
- Apaf-1 related
- Apaf-1 related killer
- Apaf-1-related killer
- Ark-PA
- Ark-PB
- CG6829-PA
- CG6829-PB
- apaf1-related killer
- dark
- drosophila Apaf-1-related killer
- lethal (2) SH0173
- transcription unit 1
- apoptotic peptidase activating factor 1
- apoptotic protease-activating factor 1-like
- apoptotic protease-activating factor 1
- apoptotic protease activating factor 1
- forebrain overgrowth
- apaf-1
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