APEX2 Produits
(APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
Catégories
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012].
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Catégories APEX2 en vedette
APEX2 Anticorps
High quality antibodies with extensive validation data.
APEX2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
APEX2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF, FACS, IHC (p)
Validations
- (4)
N° du produit
ABIN652924
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (2)
N° du produit
ABIN525954
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, FACS, IF/ICC
Validations
- (3)
N° du produit
ABIN3003990
Quantité
400 μL
Fiche technique
Fiche technique
APEX2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1130230
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1130231
Quantité
96 tests
Fiche technique
Fiche technique
APEX2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3089223
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3135636
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN2714790
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits APEX2
: "Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets." dans: Molecular cell, Vol. 73, Issue 5, pp. 885-899.e6, (2019) (PubMed).: "Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1." dans: The Journal of biological chemistry, Vol. 287, Issue 35, pp. 29801-14, (2012) (PubMed).
: "Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen." dans: Nucleic acids research, Vol. 29, Issue 11, pp. 2349-60, (2001) (PubMed).
Synonymes et noms alternatifs relatifs à APEX2
apurinic/apyrimidinic endodeoxyribonuclease 2 (APEX2), apurinic/apyrimidinic endodeoxyribonuclease 2 (apex2), APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2), apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog (apex2.L), APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2), apurinic/apyrimidinic endonuclease 2 (Apex2), apurinic/apyrimidinic endodeoxyribonuclease 2 (Apex2), APE2, ape2, APEXL2, apexl2, C430040P13Rik, XTH2, xth2, zgc:55889Protein level used designations for APEX2
- AP endonuclease 2
- AP endonuclease XTH2
- DNA-(apurinic or apyrimidinic site) lyase 2
- apurinic/apyrimidinic endonuclease-like 2
- APEX nuclease 2
- apurinic-apyrimidinic endonuclease 2
- APEX nuclease (apurinic/apyrimidinic endonuclease) 2
- DNA-(apurinic or apyrimidinic site) lyase 2-like
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