APOBEC3A Produits
(Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A))
Catégories
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012].
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Catégories APOBEC3A en vedette
APOBEC3A Anticorps
High quality antibodies with extensive validation data.
APOBEC3A recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
ELISA, WB, IHC, IF, FACS
Validations
- (4)
N° du produit
ABIN238645
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB
Validations
- (5)
- (1)
N° du produit
ABIN1881066
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
ELISA, WB, IF, ICC
Validations
- (2)
N° du produit
ABIN6259984
Quantité
100 μL
Fiche technique
Fiche technique
APOBEC3A recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3087958
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN2714811
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits APOBEC3A
: "HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages." dans: PLoS ONE, Vol. 9, Issue 8, pp. e106418, (2014) (PubMed).: "Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms." dans: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27753-66, (2010) (PubMed).
: "Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes." dans: The Journal of biological chemistry, Vol. 285, Issue 16, pp. 12248-54, (2010) (PubMed).
: "APOBEC3 proteins mediate the clearance of foreign DNA from human cells." dans: Nature structural & molecular biology, Vol. 17, Issue 2, pp. 222-9, (2010) (PubMed).
: "Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection." dans: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 39, Issue 12, pp. 1159-68, (2009) (PubMed).
: "APOBEC deaminases-mutases with defensive roles for immunity." dans: Science in China. Series C, Life sciences / Chinese Academy of Sciences, Vol. 52, Issue 10, pp. 893-902, (2009) (PubMed).
: "Targeting APOBEC3A to the viral nucleoprotein complex confers antiviral activity." dans: Retrovirology, Vol. 4, pp. 61, (2007) (PubMed).
: "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business." dans: Trends in genetics : TIG, Vol. 19, Issue 4, pp. 207-16, (2003) (PubMed).
: "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22." dans: Genomics, Vol. 79, Issue 3, pp. 285-96, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à APOBEC3A
apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A), apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (APOBEC3Z1), apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Z1 (APOBEC3Z1), similar to ARP10 protein (APOBEC3A), apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (APOBEC3A), A3A, APOBEC3A, APOBEC3Z1, ARP3, bK150C2.1, PHRBNProtein level used designations for APOBEC3A
- DNA dC->dU-editing enzyme APOBEC-3A
- phorbolin 1
- phorbolin-1
- probable DNA dC->dU-editing enzyme APOBEC-3A
- apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
- similar to ARP10 protein
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