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APOE Produits

(Apolipoprotein E (APOE))

Catégories

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008].

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Catégories APOE en vedette

APOE Anticorps

High quality antibodies with extensive validation data.

APOE Kits ELISA

Reliable ELISA kits for a wide range of species.

APOE Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

APOE recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (9)
N° du produit ABIN7429133
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (9)
N° du produit ABIN7429139
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Dog
Application WB, IHC, IP, ICC
Validations
  • (7)
N° du produit ABIN7440422
Quantité 100 μL
Fiche technique Fiche technique

APOE recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
  • (1)
N° du produit ABIN612665
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6975758
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Competition ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6974557
Quantité 96 tests
Fiche technique Fiche technique

APOE recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
N° du produit ABIN7273868
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
N° du produit ABIN7273871
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
N° du produit ABIN7273869
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits APOE

Lindner, Beckenbauer, van Ek, Titeca, de Leeuw, Awwad, Hanke, Korepanova, Rybin, van der Kam, Mohler, Tackenberg, Lakics, Gavin: "Isoform- and cell-state-specific lipidation of ApoE in astrocytes." dans: Cell reports, Vol. 38, Issue 9, pp. 110435, (2022) (PubMed).

Zhang, Zong, Jiang, Hu, Cheng, Ni, Yi, Jiang, Tian, Chang, Su, Zhu, Li, Xiang, Miao, Gorospe, de Cabo, Dou, Ju, Yang, Jiang, Yang, Wang: "Hepatic HuR modulates lipid homeostasis in response to high-fat diet." dans: Nature communications, Vol. 11, Issue 1, pp. 3067, (2020) (PubMed).

Gordon, Yao, Xu, Karkowsky, Kaler, Kalchiem-Dekel, Barochia, Gao, Keeran, Jeffries, Levine: "Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects." dans: The Journal of allergy and clinical immunology, Vol. 144, Issue 2, pp. 426-441.e3, (2020) (PubMed).

Schmid, Prehn, Nimsanor, Garcia, Poulsen, Jørring, Rasmussen, Clausen, Mau-Holzmann, Ramakrishna, Muddashetty, Steeg, Bruce, Mackintosh, Ebneth, Holst, Cabrera-Socorro: "Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line." dans: Stem cell research, Vol. 34, pp. 101349, (2019) (PubMed).

Zhao, Liu, Van Ingelgom, Linares, Kurti, Knight, Heckman, Diehl, Shinohara, Martens, Attrebi, Petrucelli, Fryer, Wszolek, Graff-Radford, Caselli, Sanchez-Contreras, Rademakers, Murray, Koga, Dickson et al.: "APOE ε2 is associated with increased tau pathology in primary tauopathy. ..." dans: Nature communications, Vol. 9, Issue 1, pp. 4388, (2019) (PubMed).

Lu, Yuan, Wang, Zhang, Yuan, Wu, Zhou, He, Lu, Chen, Fan, Liang, Cheng: "Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7." dans: EBioMedicine, Vol. 36, pp. 29-38, (2019) (PubMed).

Zimmerman, Bentley, Lever, Li, Crossman, Song, Liu, Crowley, George, Mrug, Yoder: "Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species." dans: Journal of the American Society of Nephrology : JASN, Vol. 30, Issue 5, pp. 767-781, (2019) (PubMed).

Centa, Prokopec, Garimella, Habir, Hofste, Stark, Dahdah, Tibbitt, Polyzos, Gisterå, Johansson, Maeda, Hansson, Ketelhuth, Coquet, Binder, Karlsson, Malin: "Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis." dans: Arteriosclerosis, thrombosis, and vascular biology, Vol. 38, Issue 8, pp. e145-e158, (2019) (PubMed).

Gupta, Pokhriyal, Das, Khan, Ratna Kumar, Gupta, Chadda, Ramachandran, Goyal, Tripathi, Hariprasad et al.: "Evaluation of α-synuclein and apolipoprotein E as potential biomarkers in cerebrospinal fluid to monitor pharmacotherapeutic efficacy in dopamine dictated disease states of Parkinson's disease and ..." dans: Neuropsychiatric disease and treatment, Vol. 15, pp. 2073-2085, (2019) (PubMed).

Chernukha, Fedulova, Kotenkova, Takeda, Sakata: "Hypolipidemic and anti-inflammatory effects of aorta and heart tissues of cattle and pigs in the atherosclerosis rat model." dans: Animal science journal = Nihon chikusan Gakkaihō, Vol. 89, Issue 5, pp. 784-793, (2018) (PubMed).

Synonymes et noms alternatifs relatifs à APOE

apolipoprotein E (apoe), apolipoprotein Ea (apoea), apolipoprotein E (Apoe), apolipoprotein E (APOE), ad2, AD2, AI255918, Apo-E, apoe, APOEA, apoprotein, im:7036787, LDLCQ5, LPG, wu:fb69a05, zgc:110064

Protein level used designations for APOE

  • apolipoprotein E
  • ApoE-1
  • apo-E
  • apolipoprotein E3
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