APPL2 Produits
(Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
Catégories
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011].
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Catégories APPL2 en vedette
APPL2 Anticorps
High quality antibodies with extensive validation data.
APPL2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
APPL2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
N° du produit
ABIN527415
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (3)
N° du produit
ABIN527414
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IF, IHC
Validations
- (2)
N° du produit
ABIN7149505
Quantité
100 μg
Fiche technique
Fiche technique
APPL2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6964611
Quantité
96 tests
Fiche technique
Fiche technique
APPL2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7121696
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1345412
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1345410
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits APPL2
: "Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice." dans: The European journal of neuroscience, (2019) (PubMed).: "The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle." dans: Life sciences, Vol. 210, pp. 209-213, (2018) (PubMed).
: "Acute physical exercise increases the adaptor protein APPL1 in the hypothalamus of obese mice." dans: Cytokine, Vol. 110, pp. 87-93, (2018) (PubMed).
: "The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway." dans: The Journal of endocrinology, Vol. 210, Issue 1, pp. 81-92, (2011) (PubMed).
Synonymes et noms alternatifs relatifs à APPL2
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (Appl2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog (appl2.L), adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (appl2), adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2), APPL2, Dip3b, dip13b, DIP13B, MGC84621, RGD1563028Protein level used designations for APPL2
- DCC-interacting protein 13-beta
- adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
- amyloid beta (A4) precursor-like protein 2
- DIP13 beta
- adapter protein containing PH domain, PTB domain and leucine zipper motif 2
- Dip3 beta
- dip13-beta
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