Histone H3 Antibodies

Epigenetics is the study of heritable cellular and physiological properties by factors other than DNA sequence. Examples include simple chemical modifications, such as methylation and acetylation to DNA and interacting partners. Because the structure of each base is conserved, DNA methylation is not a gene mutation but a modification. However, these modifications play a role in controlling how, where and when certain genes are expressed.

Antibodies against Histone 3 Modifications

Histon H3K27m3 - Shutting Down Transcription

H3K27me is a well-studied target of epigenetic scientists searching for inactive genes. Unlike other histone methylations, H3K27m3 has only one known methyltransferase: EZH2. EZH2 is responsible for repressing many genes involved in development and cell differentiation. Therefore, H3K27m3 is critical for the repression of developmental genes. When H3K27 is trimethylated, it is closely associated with inactive gene promoters.

The mono- and dimethylation states are less studied, but H3K27m2 shows a similar distribution to H3K27, while H3K27m1 is associated with active promoters. H3K27 may also be a target of acetylation. Lysine residues can only be methylated or acetylated, in comparison acetylation leads to opposite effects - with active transcription and antagonism of H3K27m3 regulated genes.

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