ASPM Anticorps
(Asp (Abnormal Spindle) Homolog, Microcephaly Associated (ASPM))
This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011].
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Catégories ASPM en vedette
ASPM Anticorps
High quality antibodies with extensive validation data.
ASPM recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
N° du produit
ABIN7142932
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
IF
Validations
- (3)
N° du produit
ABIN7259793
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human, Rat
Application
ELISA, IHC, IF, ICC, WB
Validations
- (3)
N° du produit
ABIN6260082
Quantité
100 μL
Fiche technique
Fiche technique
Dernières publications sur nos produits ASPM
: "Identification of Abnormal Spindle Microtubule Assembly as a Promising Therapeutic Target for Osteosarcoma." dans: Orthopaedic surgery, Vol. 12, Issue 6, pp. 1963-1970, (2021) (PubMed).: "NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells." dans: The EMBO journal, Vol. 39, Issue 2, pp. e102378, (2020) (PubMed).
: "Abnormal spindle-like microcephaly-associated protein (ASPM) contributes to the progression of Lung Squamous Cell Carcinoma (LSCC) by regulating CDK4." dans: Journal of Cancer, Vol. 11, Issue 18, pp. 5413-5423, (2020) (PubMed).
: "Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity." dans: Current biology : CB, Vol. 29, Issue 18, pp. 3072-3080.e5, (2019) (PubMed).
: "Pancreatic cancer survival analysis defines a signature that predicts outcome." dans: PLoS ONE, Vol. 13, Issue 8, pp. e0201751, (2018) (PubMed).
: "Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly." dans: Scientific reports, Vol. 7, pp. 43708, (2017) (PubMed).
: "Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex." dans: Nature cell biology, Vol. 19, Issue 5, pp. 480-492, (2017) (PubMed).
: "Time-dependent transcriptional profiling links gene expression to mitogen-activated protein kinase kinase 4 (MKK4)-mediated suppression of omental metastatic colonization." dans: Clinical & experimental metastasis, Vol. 29, Issue 5, pp. 397-408, (2012) (PubMed).
: "Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling." dans: Nature genetics, Vol. 40, Issue 2, pp. 232-6, (2008) (PubMed).
Synonymes et noms alternatifs relatifs à ASPM
abnormal spindle microtubule assembly (Aspm), abnormal spindle microtubule assembly (ASPM), abnormal spindle microtubule assembly (aspm), asp (abnormal spindle)-like, microcephaly associated (Drosophila) (Aspm), ASP, ASPM, Calmbp1, D330028K02Rik, MCPH5, Sha1Protein level used designations for ASPM
- asp (abnormal spindle) homolog, microcephaly associated
- calmodulin binding protein 1
- asp (abnormal spindle)-like, microcephaly associated
- asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
- Abnormal spindle-like microcephaly-associated protein homolog
- abnormal spindle-like microcephaly-associated protein
- abnormal spindle-like microcephaly-associated protein homolog
- abnormal spindle-like microcephaly protein
- calmodulin-binding protein 1
- calmodulin-binding protein Sha1
- spindle and hydroxyurea checkpoint abnormal protein
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