ASXL1 Produits
(Additional Sex Combs Like 1 (ASXL1))
Catégories
This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].
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Catégories ASXL1 en vedette
ASXL1 Anticorps
High quality antibodies with extensive validation data.
ASXL1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
ASXL1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (5)
N° du produit
ABIN949894
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, FACS, IF, IHC (p)
Validations
- (4)
N° du produit
ABIN655084
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, FACS, IF, IHC (p), EIA
Validations
- (4)
N° du produit
ABIN950543
Quantité
0.4 mL
Fiche technique
Fiche technique
ASXL1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7121702
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1345902
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN1692425
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits ASXL1
: "Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex." dans: Nature communications, Vol. 6, pp. 7307, (2015) (PubMed).: "Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34? progenitor cells." dans: British journal of haematology, Vol. 160, Issue 6, pp. 842-50, (2013) (PubMed).
: "A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11." dans: Gene, Vol. 306, pp. 115-26, (2003) (PubMed).
Synonymes et noms alternatifs relatifs à ASXL1
additional sex combs like 1, transcriptional regulator L homeolog (asxl1.L), additional sex combs like 1, transcriptional regulator (ASXL1), additional sex combs like 1, transcriptional regulator (asxl1), additional sex combs like 1 (Asxl1), asxl1, BOPS, MDS, MGC83850, mKIAA0978Protein level used designations for ASXL1
- additional sex combs like 1
- additional sex combs-like protein 1
- putative Polycomb group protein ASXL1
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