Ataxin 2 Produits
(Ataxin 2 (ATXN2))
Catégories
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. This locus has been mapped to chromosome 12, and it has been determined that the diseased allele contains 37-50 CAG repeats, compared to 17-29 in the normal allele. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined. [provided by RefSeq, Jan 2010].
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Catégories Ataxin 2 en vedette
Ataxin 2 Anticorps
High quality antibodies with extensive validation data.
Ataxin 2 Kits ELISA
Reliable ELISA kits for a wide range of species.
Ataxin 2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Ataxin 2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (5)
N° du produit
ABIN7259314
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IF, ICC, FACS
Validations
- (7)
N° du produit
ABIN3028477
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (3)
N° du produit
ABIN872411
Quantité
100 μL
Fiche technique
Fiche technique
Ataxin 2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6962049
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN1113614
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN1113615
Quantité
96 tests
Fiche technique
Fiche technique
Ataxin 2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7121916
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346193
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7505038
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits Ataxin 2
: "Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids." dans: Nucleic acids research, Vol. 44, Issue 18, pp. 8870-8884, (2016) (PubMed).: "Generation of human-induced pluripotent stem cells to model spinocerebellar ataxia type 2 in vitro." dans: Journal of molecular neuroscience : MN, Vol. 51, Issue 2, pp. 237-48, (2013) (PubMed).
: "Ataxin-2-like is a regulator of stress granules and processing bodies." dans: PLoS ONE, Vol. 7, Issue 11, pp. e50134, (2012) (PubMed).
: "Multiple common variants for celiac disease influencing immune gene expression. ..." dans: Nature genetics, Vol. 42, Issue 4, pp. 295-302, (2010) (PubMed).
: "Expression of ataxin-2 in brains from normal individuals and patients with Alzheimer's disease and spinocerebellar ataxia 2." dans: Annals of neurology, Vol. 45, Issue 2, pp. 232-41, (1999) (PubMed).
: "The mouse SCA2 gene: cDNA sequence, alternative splicing and protein expression." dans: Human molecular genetics, Vol. 7, Issue 8, pp. 1301-9, (1998) (PubMed).
: "Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2." dans: Nature genetics, Vol. 14, Issue 3, pp. 269-76, (1996) (PubMed).
Synonymes et noms alternatifs relatifs à Ataxin 2
ataxin 2 (ATXN2), ataxin 2 (Atxn2), ataxin 2 L homeolog (atxn2.L), 9630045M23Rik, ASL13, ATX2, ATXN2, AW544490, MGC115230, SCA2, Sca2, TNRC13Protein level used designations for Ataxin 2
- ataxin-2
- spinocerebellar ataxia type 2 protein
- trinucleotide repeat containing 13
- trinucleotide repeat-containing gene 13 protein
- spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2)
- spinocerebellar ataxia 2 homolog
- spinocerebellar ataxia type 2 protein homolog
- ataxin 2
- ataxin-2-like
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