This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008].
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Magalon, Le Grand, El Waly, Moulis, Pruss, Bordet, Cayre, Belenguer, Carré, Durbec: "Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules." dans: Neuropharmacology, Vol. 111, pp. 293-303, (2017) (PubMed).
Synonymes et noms alternatifs relatifs à ATP5C1
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (ATP5C1), ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (Atp5c1), 1700094F02Rik, ATP5C, ATP5CL1
Protein level used designations for ATP5C1
ATP synthase gamma chain, mitochondrial
ATP synthase subunit gamma, mitochondrial
F-ATPase gamma subunit
mitochondrial ATP synthase, gamma subunit 1
ATP synthase gamma-subunit gene encoding a mitochondrial protein