ATRX Produits
(helicase 2, X-linked (ATRX))
Catégories
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Catégories ATRX en vedette
ATRX Anticorps
High quality antibodies with extensive validation data.
ATRX Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
ATRX recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Application
WB, IF, IHC (p), ICC, IP
Validations
- (7)
N° du produit
ABIN2855005
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IF, IHC
Validations
- (3)
N° du produit
ABIN7172767
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA
Validations
- (3)
N° du produit
ABIN5611354
Quantité
100 μL
Fiche technique
Fiche technique
ATRX recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346185
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346187
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Macropus eugenii
Source
Yeast
Validations
N° du produit
ABIN1609565
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits ATRX
: "Telomere elongation via alternative lengthening of telomeres (ALT) and telomerase activation in primary metastatic medulloblastoma of childhood." dans: Journal of neuro-oncology, Vol. 142, Issue 3, pp. 435-444, (2019) (PubMed).: "A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer." dans: Oncology letters, Vol. 16, Issue 5, pp. 6652-6662, (2018) (PubMed).
: "Dysregulation of select ATP-dependent chromatin remodeling factors in high trait anxiety." dans: Behavioural brain research, Vol. 311, pp. 141-6, (2016) (PubMed).
: "Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas." dans: Nature communications, Vol. 6, pp. 6140, (2015) (PubMed).
: "Molecular-genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort." dans: Oncotarget, Vol. 6, Issue 18, pp. 15871-81, (2015) (PubMed).
: "ATRX represses alternative lengthening of telomeres." dans: Oncotarget, Vol. 6, Issue 18, pp. 16543-58, (2015) (PubMed).
: "TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast." dans: British journal of cancer, Vol. 113, Issue 8, pp. 1244-8, (2015) (PubMed).
: "Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors." dans: Frontiers in behavioral neuroscience, Vol. 9, pp. 313, (2015) (PubMed).
: "Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH." dans: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 32, Issue 8, pp. 783-90, (2014) (PubMed).
: "Clinical Neuropathology practice news 2-2014: ATRX, a new candidate biomarker in gliomas." dans: Clinical neuropathology, Vol. 33, Issue 2, pp. 108-11, (2014) (PubMed).
Synonymes et noms alternatifs relatifs à ATRX
ATRX, chromatin remodeler (ATRX), ATRX, chromatin remodeler (Atrx), alpha thalassemia/mental retardation syndrome X-linked L homeolog (atrx.L), alpha thalassemia/mental retardation syndrome X-linked homolog (human) (atrx), 4833408C14Rik, AI447451, ATR2, atrx, atrxl, DXHXS6677E, HP1-BP38, Hp1bp2, Hp1bp38, JMS, MRXHF1, MRXS3, RAD54, Rad54, rad54, RAD54L, SFM1, SHS, wu:fb26e12, wu:fb52h08, wu:fb72g09, wu:fb94e07, XH2, XNP, Xnp, zgc:66223, ZNF-HXProtein level used designations for ATRX
- ATP-dependent helicase ATRX
- DNA dependent ATPase and helicase
- X-linked helicase II
- X-linked nuclear protein
- Zinc finger helicase
- alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)
- helicase 2, X-linked
- transcriptional regulator ATRX
- HP1 alpha-interacting protein
- alpha thalassemia/mental retardation syndrome (X-linked)
- heterochromatin protein 2
- alpha thalassemia/mental retardation syndrome X-linked homolog
- helicase II
- pABP-2
- XNP
- alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog)
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